Photogenerated Holes Mediated Nitric Oxide Production for Hypoxic Tumor Treatment

被引：91

作者：

Fang, Xiao ^{[1
]}

Cai, Shuxian ^{[1
]}

Wang, Min ^{[1
]}

Chen, Zhaowei ^{[1
]}

Lu, Chunhua ^{[1
]}

Yang, Huanghao ^{[1
]}

机构：

[1] Fuzhou Univ, State Key Lab Photocatalysis Energy & Environm, Fujian Prov Key Lab Anal & Detect Technol Food Sa, Coll Chem,MOE Key Lab Analyt Sci Food Safety & Bi, Fuzhou 350108, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2021年 / 60卷 / 13期

基金：

国家重点研发计划; 中国国家自然科学基金;

关键词：

cancer; hypoxia; microenvironment; nitric oxide; photochemistry;

D O I：

10.1002/anie.202015082

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Nitric oxide (NO) is a gaseous signal molecule with multiple physiological functions, and it also plays a key role in cancer therapy. However, the production of NO which depends on O-2 or H2O2 is limited within the tumor microenvironment, leading to unsatisfactory anticancer effect. Herein, we report a NO-based phototherapeutic strategy mediated by photogenerated holes for hypoxic tumors, which is achieved by irradiation of the poly-L-arginine modified carbon-dots-doped graphitic carbon nitride nanomaterial (ArgCCN). Upon red light irradiation, the photogenerated holes on ArgCCN oxidized water into H2O2 which subsequently oxidized the arginine residues to produce NO. In vitro and in vivo experiments showed that the high concentration of NO produced by ArgCCN could induce cancer cell apoptosis. The presented phototherapeutic strategy is based on microenvironment-independent photogenerated holes mediated oxidation reaction, paving the way for the development of NO therapeutic strategy.

引用

页码：7046 / 7050

页数：5

共 44 条

[1] Nitric oxide-mediated mitochondrial damage: A potential neuroprotective role for glutathione [J].