The Role of Placental Hormones in Mediating Maternal Adaptations to Support Pregnancy and Lactation

被引：286
作者：
Napso, Tina [1 ]
Yong, Hannah E. J. [1 ]
Lopez-Tello, Jorge [1 ]
Sferruzzi-Perri, Amanda N. [1 ]
机构：
[1] Univ Cambridge, Ctr Trophoblast Res, Dept Physiol Dev & Neurosci, Cambridge, England
来源：
FRONTIERS IN PHYSIOLOGY | 2018年 / 9卷
关键词：
pregnancy; placenta; hormones; maternal adaptations; metabolism; fetal growth; endocrine; cardiovascular; HUMAN CHORIONIC-GONADOTROPIN; THYROTROPIN-RELEASING-HORMONE; BETA-CELL MASS; ESTROGEN-RECEPTOR-ALPHA; ENDOTHELIAL GROWTH-FACTOR; NATURAL-KILLER-CELLS; LONG-TERM CONTROL; GESTATIONAL DIABETES-MELLITUS; SERUM LEPTIN CONCENTRATIONS; ENHANCED INSULIN-SECRETION;
D O I：
10.3389/fphys.2018.01091
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
During pregnancy, the mother must adapt her body systems to support nutrient and oxygen supply for growth of the baby in utero and during the subsequent lactation. These include changes in the cardiovascular, pulmonary, immune and metabolic systems of the mother. Failure to appropriately adjust maternal physiology to the pregnant state may result in pregnancy complications, including gestational diabetes and abnormal birth weight, which can further lead to a range of medically significant complications for the mother and baby. The placenta, which forms the functional interface separating the maternal and fetal circulations, is important for mediating adaptations in maternal physiology. It secretes a plethora of hormones into the maternal circulation which modulate her physiology and transfers the oxygen and nutrients available to the fetus for growth. Among these placental hormones, the prolactin-growth hormone family, steroids and neuropeptides play critical roles in drivingmaternal physiological adaptations during pregnancy. This review examines the changes that occur in maternal physiology in response to pregnancy and the significance of placental hormone production in mediating such changes.
引用
收藏
页数：39
相关论文
共 162 条
  • [1] Abd-Allah A.R., El-Sayed El S.M., Abdel-Wahab M.H., Hamada F.M., Effect of melatonin on estrogen and progesterone receptors in relation to uterine contraction in rats, Pharmacol. Res, 47, pp. 349-354, (2003)
  • [2] Abribat T., Lapierre H., Dubreuil P., Pelletier G., Gaudreau P., Brazeau P., Et al., Insulin-like growth factor-I concentration in Holstein female cattle: variations with age, stage of lactation and growth hormone-releasing factor administration, Domest. Anim. Endocrinol, 7, pp. 93-102, (1990)
  • [3] Acikgoz S., Bayar U.O., Can M., Guven B., Mungan G., Dogan S., Et al., Levels of oxidized LDL, estrogens, and progesterone in placenta tissues and serum paraoxonase activity in preeclampsia, Mediators Inflamm, 2013, (2013)
  • [4] Ackermann A.M., Gannon M., Molecular regulation of pancreatic beta-cell mass development, maintenance, and expansion, J. Mol. Endocrinol, 38, pp. 193-206, (2007)
  • [5] Adamah-Biassi E.B., Hudson R.L., Dubocovich M.L., Genetic deletion of MT1 melatonin receptors alters spontaneous behavioral rhythms in male and female C57BL/6 mice, Horm. Behav, 66, pp. 619-627, (2014)
  • [6] Adamova Z., Ozkan S., Khalil R.A., Vascular and cellular calcium in normal and hypertensive pregnancy, Curr. Clin. Pharmacol, 4, pp. 172-190, (2009)
  • [7] Ahmed-Sorour H., Bailey C.J., Role of ovarian hormones in the long-term control of glucose homeostasis. Interaction with insulin, glucagon and epinephrine, Horm. Res, 13, pp. 396-403, (1980)
  • [8] Ahmed-Sorour H., Bailey C.J., Role of ovarian hormones in the long-term control of glucose homeostasis, glycogen formation and gluconeogenesis, Ann. Nutr. Metab, 25, pp. 208-212, (1981)
  • [9] Ahn J.M., Jung H.K., Cho C., Choi D., Mayo K.E., Cho B.N., Changes in the reproductive functions of mice due to injection of a plasmid expressing an inhibin alpha-subunit into muscle: a transient transgenic model, Mol. Cells, 18, pp. 79-86, (2004)
  • [10] Ahumada-Solorzano S.M., Martinez-Moreno C.G., Carranza M., Avila-Mendoza J., Luna-Acosta J.L., Harvey S., Et al., Autocrine/paracrine proliferative effect of ovarian GH and IGF-I in chicken granulosa cell cultures, Gen. Comp. Endocrinol, 234, pp. 47-56, (2016)
12345678910