Silicate Nephrolithiasis After Ingestion of Supplements Containing Silica Dioxide

被引：13

作者：

Flythe, Jennifer E.

Rueda, Jose F. ^{[2
]}

Riscoe, Michael K. ^{[3
]}

Watnick, Suzanne ^{[1
,2
]}

机构：

[1] Portland VA Med Ctr, P3NEPH, Div Hosp & Specialty Med, Portland, OR 97239 USA

[2] Oregon Hlth & Sci Univ, Dept Med, Div Nephrol & Hypertens, Portland, OR 97201 USA

[3] Portland VA Med Ctr, Res & Dev Serv, Portland, OR USA

来源：

AMERICAN JOURNAL OF KIDNEY DISEASES | 2009年 / 54卷 / 01期

关键词：

Silicate; silica; nephrolithiasis; over-the-counter supplements; MAGNESIUM TRISILICATE; URINARY CALCULI; UROLITHIASIS;

D O I：

10.1053/j.ajkd.2008.10.042

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Silicate calculi are common in some mammals, such as dogs and sheep, but extremely rare in humans. We report a case of silicate calculi in a woman using oral over-the-counter Uncaria tomentosa, Digestive Advantage and FlexProtex supplements. All 3 contained the excipient silica dioxide. Stone analysis showed composition of 100% silicate. The nephrolithiasis promptly abated after discontinuation of the products containing silica, then returned when the patient restarted her supplements. This case emphasizes the importance of stone analysis when obvious causes of nephrolithiasis are unclear and highlights the concerns of using over-the-counter supplements without substantial oversight. Am J Kidney Dis 54:127-130. (c) 2009 by the National Kidney Foundation, Inc.

引用

页码：127 / 130

页数：4

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