An engineered linker capable of promoting on-resin reactions for microwave-assisted solid-phase organic synthesis

被引：23
|
作者：
Sun, Li-Ping [1 ]
Dai, Wei-Min [1 ]
机构：
[1] Hong Kong Univ Sci & Technol, Dept Chem, Kowloon, Hong Kong, Peoples R China
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 43期
关键词：
heteroannulation; heterocycles; heterogeneous catalysis; microwave-assisted reactions; solid-phase synthesis;
D O I：
10.1002/anie.200602523
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An active link: A diglycine-containing linker (cat·linker) was fabricated on Rink amide resin for dual functions: a) attachment of a scaffold and b) capture of metal ions for promoting on-resin reactions (see picture). The metal-catching feature of the linker proves essential for the solid-phase synthesis of indoles through microwave-assisted CuII-mediated heteroannulation. (Figure Presented). © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：7255 / 7258
页数：4
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