An engineered linker capable of promoting on-resin reactions for microwave-assisted solid-phase organic synthesis

被引：23

作者：

Sun, Li-Ping ^{[1
]}

Dai, Wei-Min ^{[1
]}

机构：

[1] Hong Kong Univ Sci & Technol, Dept Chem, Kowloon, Hong Kong, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 43期

关键词：

heteroannulation; heterocycles; heterogeneous catalysis; microwave-assisted reactions; solid-phase synthesis;

D O I：

10.1002/anie.200602523

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An active link: A diglycine-containing linker (cat·linker) was fabricated on Rink amide resin for dual functions: a) attachment of a scaffold and b) capture of metal ions for promoting on-resin reactions (see picture). The metal-catching feature of the linker proves essential for the solid-phase synthesis of indoles through microwave-assisted CuII-mediated heteroannulation. (Figure Presented). © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：7255 / 7258

页数：4

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