Design and synthesis of fluconazole/bile acid conjugate using click reaction

被引：100

作者：

Pore, Vandana S. ^{[1
]}

Aher, Nilkanth G.

Kumar, Manish

Shukla, Praveen K.

机构：

[1] Natl Chem Lab, Div Organ Chem Synth, Pune 411008, Maharashtra, India

[2] Cent Drug Res Inst, Div Fermentat Technol, Lucknow 226001, Uttar Pradesh, India

来源：

TETRAHEDRON | 2006年 / 62卷 / 48期

关键词：

bile acid; fluconazole/bile acid conjugate; click chemistry; antifungal agent; 1,2,3-triazole;

D O I：

10.1016/j.tet.2006.09.021

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Novel fluconazole/bile acid conjugates were designed and their regioselective synthesis was achieved in very high yield via Cu(I) catalyzed intermolecular 1,3-dipolar cycloaddition. These new molecules showed good antifungal activity against Candida species. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：11178 / 11186

页数：9

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