Eremophilane and Cadinene Sesquiterpenes from Syringa oblata and Their Protective Effects against Hypoxia-Induced Injury on H9c2 Cells

被引：7

作者：

Tai, Badalahu ^{[1
,2
]}

Bai, Laxinamujila ^{[2
]}

Yu, Muyao ^{[3
]}

Liu, Juan ^{[3
]}

Zheng, Han ^{[3
]}

Huang, Luqi ^{[1
,3
]}

机构：

[1] Changchun Univ Chinese Med, Sch Pharmaceut Sci, Changchun 130117, Peoples R China

[2] Inner Mongolia Minzu Univ, Mongolian Med Coll, Tongliao 028000, Peoples R China

[3] China Acad Chinese Med Sci, Natl Resource Ctr Chinese Mat Med, Beijing 100700, Peoples R China

来源：

CHEMISTRY & BIODIVERSITY | 2022年 / 19卷 / 05期

关键词：

Syringa oblata; sesquiterpene; oblatanoids A-C; cardioprotective effect;

D O I：

10.1002/cbdv.202200154

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Seven sesquiterpenes including four eremophilanes (1-4) and three cadinenes (5-7), were isolated from the heartwood of Syringa oblata Lindl. Among them, three new eremophilane-type sesquiterpenes were identified and named oblatanoids A-C (1-3), respectively. Their structures were established by extensive analyses of spectroscopic methods, and their absolute configurations were determined by electronic circular dichroism (ECD) calculations. All these new compounds were evaluated for protective effects against hypoxia-induced injury on H9c2 cells, and 1-3 exhibited significantly protective activities toward H9c2 cells in vitro.

引用

页数：8

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