Growth of rotaviruses in primary pancreatic cells

被引：32

作者：

Coulson, BS ^{[1
]}

Witterick, PD

Tan, Y

Hewish, MJ

Mountford, JN

Harrison, LC

Honeyman, MC

机构：

[1] Univ Melbourne, Dept Microbiol & Immunol, Royal Parade, Vic 3010, Australia

[2] Walter & Eliza Hall Inst Med Res, Autoimmun & Transplantat Div, Melbourne, Vic 3050, Australia

来源：

JOURNAL OF VIROLOGY | 2002年 / 76卷 / 18期

关键词：

D O I：

10.1128/JVI.76.18.9537-9544.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Rotavirus infection in children at risk of developing type 1 diabetes has been temporally associated with development of pancreatic islet autoantibodies. In this study, nonobese diabetic mice were shown to be susceptible to rhesus rotavirus infection and pancreatic islets from nonobese diabetic mice, nonobese diabetes-resistant mice, fetal pigs, and macaque monkeys supported various degrees of rotavirus growth. Human rotaviruses replicated in monkey islets only. This islet susceptibility shows that rotavirus infection of the pancreas in vivo might be possible.

引用

页码：9537 / 9544

页数：8

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