Three Novel Sesquiterpene Esters from Celastrus angulatus

被引：0

作者：

Wei, Shaopeng ^{[1
]}

Wang, Mingan ^{[2
]}

Zhang, Jiwen ^{[1
]}

Qian, Yong ^{[3
]}

Ji, Zhiqin ^{[1
]}

Wu, Wenjun ^{[1
]}

机构：

[1] NW A&F Univ, Inst Pesticide Sci, Shaanxi 712100, Peoples R China

[2] China Agr Univ, Coll Sci, Beijing 100193, Peoples R China

[3] Nat Stand Biotechnol Co Ltd, Shanghai 201203, Peoples R China

来源：

NATURAL PRODUCT COMMUNICATIONS | 2009年 / 4卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Celastrus angulatus; beta-dihydroagarofuran sesquiterpene; insecticidal activity; antitumor activity; INSECTICIDAL SESQUITERPENOIDS; POLYOL ESTERS; ORBICULATUS; CELANGULIN;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Three new sesquiterpene polyol esters with a beta-dihydroagarofuran skeleton, NW 12 (1), NW27 (2), and NW31 (4), together with a known compound, NW30 (3), were isolated from the root bark of Celastrus angulatus. Their chemical structures were elucidated by analyses of MS and NMR spectral data. Preliminary insecticidal and antitumor activities of these compounds were evaluated. Compounds 14 showed moderate stomach toxicity against Mythimna separata, and their KD50 values were 673.6, 1121.3, 1720.0 and 548.6 mu g/g, respectively. Only 1 and 3 exhibited slight antitumor activity against human breast cancer cell line (Bcap-37), and their IC50 values were all above 50 mu M.

引用

页码：461 / 466

页数：6

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