Longitudinal changes in emotional functioning following pediatric resective epilepsy surgery: 2-Year follow-up

被引：4

作者：

Phillips, Natalie L. ^{[1
,2
]}

Widjaja, Elysa ^{[1
,3
,4
]}

Speechley, Kathy ^{[5
,6
,7
]}

Ferro, Mark ^{[8
]}

Connolly, Mary ^{[9
]}

Major, Philippe ^{[10
]}

Gallagher, Anne ^{[11
]}

Ramachandrannair, Rajesh ^{[12
]}

Almubarak, Salah ^{[13
,14
]}

Hasal, Simona ^{[13
,14
]}

Andrade, Andrea ^{[15
]}

Xu, Qi ^{[16
]}

Leung, Edward ^{[16
]}

Snead, O. Carter, III ^{[3
]}

Smith, Mary Lou ^{[1
,2
,17
]}

机构：

[1] Hosp Sick Children, Neurosci & Mental Hlth Program, Toronto, ON, Canada

[2] Hosp Sick Children, Dept Psychol, Toronto, ON, Canada

[3] Hosp Sick Children, Div Neurol, Toronto, ON, Canada

[4] Hosp Sick Children, Dept Diagnost Imaging, Toronto, ON, Canada

[5] Western Univ, Dept Paediat, London, ON, Canada

[6] Western Univ, Dept Epidemiol, London, ON, Canada

[7] Western Univ, Dept Biostat, London, ON, Canada

[8] Univ Waterloo, Sch Publ Hlth & Hlth Syst, Waterloo, ON, Canada

[9] BC Childrens Hosp, Dept Pediat, Div Neurol, Vancouver, BC, Canada

[10] Ste Justine Hosp, Dept Pediat, Div Neurol, Montreal, PQ, Canada

[11] Ste Justine Hosp, Ctr Rech, Montreal, PQ, Canada

[12] McMaster Univ, Dept Pediat, Hamilton, ON, Canada

[13] Royal Univ Hosp, Neurol Div, Dept Pediat, Saskatoon, SK, Canada

[14] Qatif Cent Hosp, Dept Pediat, Neurol Div, Qatif, Saudi Arabia

[15] Univ Western Ontario, London Hlth Sci Ctr, Dept Pediat, London, ON, Canada

[16] Hlth Sci Ctr, Dept Pediat, Winnipeg, MB, Canada

[17] Univ Toronto Mississauga, Dept Psychol, 3359 Mississauga Rd, Mississauga, ON L5L 1C6, Canada

来源：

EPILEPSY & BEHAVIOR | 2021年 / 114卷

关键词：

Anxiety; Depression; Pediatric drug-resistant epilepsy; Resective surgery; Seizures; QUALITY-OF-LIFE; GENERALIZED ANXIETY DISORDER; REVISED CHILD ANXIETY; FAMILY FACTORS; DEPRESSION; OUTCOMES; SYMPTOMS; PSYCHOPATHOLOGY; ADOLESCENTS; NORMALITY;

D O I：

10.1016/j.yebeh.2020.107585

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Objective: To examine longitudinal changes and predictors of depression and anxiety 2 years following resective epilepsy surgery, compared to no surgery, in children with drug-resistant epilepsy (DRE). Method: This multicenter cohort study involved 128 children and adolescents with DRE (48 surgical, 80 nonsurgical; 8-18 years) who completed self-report measures of depression and anxiety at baseline and follow-up (6-month, 1-year, 2-year). Child demographic (age, sex, IQ) and seizure (age at onset, duration, frequency, site and side) variables were collected. Results: Linear mixed-effects models controlling for age at enrolment found a time by treatment by seizure outcome interaction for depression. A negative linear trend across time (reduction in symptoms) was found for surgical patients, irrespective of seizure outcome. In contrast, the linear trend differed depending on seizure outcome in nonsurgical patients; a negative trend was found for those with continued seizures, whereas a positive trend (increase in symptoms) was found for those who achieved seizure freedom. Only a main effect of time was found for anxiety indicating a reduction in symptoms across patient groups. Multivariate regressions failed to find baseline predictors of depression or anxiety at 2-year follow-up in surgical patients. Older age, not baseline anxiety or depression, predicted greater symptoms of anxiety and depression at 2-year follow-up in nonsurgical patients. Conclusion: Children with DRE reported improvement in anxiety and depression, irrespective of whether they achieve seizure control, across the 2 years following surgery. In contrast, children with DRE who did not undergo surgery, but achieved seizure freedom, reported worsening of depressive symptoms, which may indicate difficulty adjusting to life without seizures and highlight the potential need for ongoing medical and psychosocial follow-up and support. (C) 2020 Elsevier Inc. All rights reserved.

引用

页数：8

共 39 条

[1] CHILD ADOLESCENT BEHAVIORAL AND EMOTIONAL-PROBLEMS - IMPLICATIONS OF CROSS-INFORMANT CORRELATIONS FOR SITUATIONAL SPECIFICITY [J].

ACHENBACH, TM ;

MCCONAUGHY, SH ;

HOWELL, CT .

PSYCHOLOGICAL BULLETIN, 1987, 101 (02) :213-232

[2] Effects of surgical side and site on mood and behavior outcome in children with pharmacoresistant epilepsy [J].

Andresen, Elizabeth N. ;

Ramirez, Maya J. ;

Kim, Kevin H. ;

Dorfman, Ava B. ;

Haut, Jennifer S. ;

Klaas, Patricia A. ;

Jehi, Lara E. ;

Shea, Katherine ;

Bingaman, William E. ;

Busch, Robyn M. .

FRONTIERS IN NEUROLOGY, 2014, 5

[3] Psychiatric and neurodevelopmental disorders in childhood-onset epilepsy [J].

Berg, Anne T. ;

Caplan, Rochelle ;

Hesdorffer, Dale C. .

EPILEPSY & BEHAVIOR, 2011, 20 (03) :550-555

[4] Psychometric properties of the revised child anxiety and depression scale in a clinical sample [J].

Chorpita, BF ;

Moffitt, CE ;

Gray, J .

BEHAVIOUR RESEARCH AND THERAPY, 2005, 43 (03) :309-322

[5] Assessment of symptoms of DSM-IV anxiety and depression in children: a revised child anxiety and depression scale [J].

Chorpita, BF ;

Yim, L ;

Moffitt, C ;

Umemoto, LA ;

Francis, SE .

BEHAVIOUR RESEARCH AND THERAPY, 2000, 38 (08) :835-855

[6] Correlates of health-related quality of life in children with drug resistant epilepsy [J].

Conway, Lauryn ;

Smith, Mary Lou ;

Ferro, Mark A. ;

Speechley, Kathy N. ;

Connoly, Mary B. ;

Snead, O. Carter ;

Widjaja, Elysa .

EPILEPSIA, 2016, 57 (08) :1256-1264

[7] Informant discrepancies in the assessment of childhood psychopathology: A critical review, theoretical framework, and recommendations for further study [J].

De Los Reyes, A ;

Kazdin, AE .

PSYCHOLOGICAL BULLETIN, 2005, 131 (04) :483-509

[8] Quality of life in young adults who underwent resective surgery for epilepsy in childhood [J].

Elliott, Irene ;

Kadis, Darren S. ;

Lach, Lucyna ;

Olds, Janet ;

McCleary, Lynn ;

Whiting, Sharon ;

Snyder, Thomas ;

Smith, Mary Lou .

EPILEPSIA, 2012, 53 (09) :1577-1586

[9] Psychosocial outcomes in children two years after epilepsy surgery: Has anything changed? [J].

Elliott, Irene M. ;

Lach, Lucyna ;

Kadis, Darren S. ;

Smith, Mary Lou .

EPILEPSIA, 2008, 49 (04) :634-641

[10] Screening for Depression and Anxiety in Epilepsy [J].

Fiest, Kirsten M. ;

Patten, Scott B. ;

Jette, Nathalie .

NEUROLOGIC CLINICS, 2016, 34 (02) :351-+

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