Adamantane-based amphiphiles (ADAs) for membrane protein study: importance of a detergent hydrophobic group in membrane protein solubilisation

被引：8

作者：

Chae, Pit Seok ^{[1
]}

Bae, Hyoung Eun ^{[1
]}

Das, Manabendra ^{[1
]}

机构：

[1] Hanyang Univ, Dept Bionanotechnol, Ansan 426791, South Korea

来源：

CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 82期

基金：

新加坡国家研究基金会;

关键词：

MUSCARINIC ACETYLCHOLINE-RECEPTOR; GLYCOL GNG AMPHIPHILES; AQUEOUS-SOLUTIONS; CRYSTAL-STRUCTURE; FACIAL AMPHIPHILES; COUPLED RECEPTOR; MNG AMPHIPHILES; STABILIZATION; SURFACTANTS; CRYSTALLIZATION;

D O I：

10.1039/c4cc05746e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We prepared adamantane-containing amphiphiles and evaluated them using a large membrane protein complex in terms of protein solubilisation and stabilization efficacy. These agents were superior to conventional detergents, especially in terms of the membrane protein solubilisation efficiency, implying a new detergent structure-property relationship.

引用

页码：12300 / 12303

页数：4

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