Adamantane-based amphiphiles (ADAs) for membrane protein study: importance of a detergent hydrophobic group in membrane protein solubilisation

被引：8
|
作者：
Chae, Pit Seok [1 ]
Bae, Hyoung Eun [1 ]
Das, Manabendra [1 ]
机构：
[1] Hanyang Univ, Dept Bionanotechnol, Ansan 426791, South Korea
来源：
CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 82期
基金：
新加坡国家研究基金会;
关键词：
MUSCARINIC ACETYLCHOLINE-RECEPTOR; GLYCOL GNG AMPHIPHILES; AQUEOUS-SOLUTIONS; CRYSTAL-STRUCTURE; FACIAL AMPHIPHILES; COUPLED RECEPTOR; MNG AMPHIPHILES; STABILIZATION; SURFACTANTS; CRYSTALLIZATION;
D O I：
10.1039/c4cc05746e
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We prepared adamantane-containing amphiphiles and evaluated them using a large membrane protein complex in terms of protein solubilisation and stabilization efficacy. These agents were superior to conventional detergents, especially in terms of the membrane protein solubilisation efficiency, implying a new detergent structure-property relationship.
引用
收藏
页码：12300 / 12303
页数：4
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