25 Years of Proton Pump Inhibitors: A Comprehensive Review

被引：420

作者：

Strand, Daniel S. ^{[1
]}

Kim, Daejin ^{[2
]}

Peura, David A. ^{[1
]}

机构：

[1] Univ Virginia, Div Gastroenterol & Hepatol, POB 800708, Charlottesville, VA 22908 USA

[2] Daegu Fatima Hosp, Div Gastroenterol, Daegu, South Korea

来源：

GUT AND LIVER | 2017年 / 11卷 / 01期

关键词：

Proton pump inhibitors; Review; Pharmacokinetics; Indications; Risk; GASTROESOPHAGEAL-REFLUX DISEASE; ZOLLINGER-ELLISON-SYNDROME; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; CONTROLLED CLINICAL-TRIALS; ACID-RELATED DISORDERS; ESOMEPRAZOLE; 40; MG; HELICOBACTER-PYLORI INFECTION; COMMUNITY-ACQUIRED PNEUMONIA; RABEPRAZOLE EXTENDED-RELEASE; EXPERT CONSENSUS DOCUMENT;

D O I：

10.5009/gnl15502

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Proton pump inhibitors (PPIs) were clinically introduced more than 25 years ago and have since proven to be invaluable, safe, and effective agents for the management of a variety of acid-related disorders. Although all members in this class act in a similar fashion, inhibiting active parietal cell acid secretion, there are slight differences among PPIs relating to their pharmacokinetic properties, metabolism, and Food and Drug Administration (FDA)-approved clinical indications. Nevertheless, each is effective in managing gastroesophageal reflux disease and uncomplicated or complicated peptic ulcer disease. Despite their overall efficacy, PPIs do have some limitations related to their short plasma half-lives and requirement for meal-associated dosing, which can lead to breakthrough symptoms in some individuals, especially at night. Longer acting PPIs and technology to prolong conventional PPI activity have been developed to specifically address these limitations and may improve clinical outcomes.

引用

页码：27 / 37

页数：11

共 102 条

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