Upregulation of Human Mammaglobin Reduces Migration and Invasion of Breast Cancer Cells

被引：17

作者：

Koh, Eun-Ha ^{[2
]}

Cho, Young-Woo ^{[1
]}

Mun, Yun-Ja ^{[1
]}

Ryu, Ji Hyeon ^{[1
]}

Kim, Eun-Jin ^{[1
]}

Choi, Dae Seob ^{[3
]}

Maeng, Kook-Young ^{[2
]}

Han, Jaehee ^{[1
]}

Kang, Dawon ^{[1
]}

机构：

[1] Gyeongsang Natl Univ, Sch Med, Inst Hlth Sci, Dept Physiol, Jinju, South Korea

[2] Gyeongsang Natl Univ, Sch Med, Inst Hlth Sci, Dept Lab Med, Jinju, South Korea

[3] Gyeongsang Natl Univ, Sch Med, Inst Hlth Sci, Dept Radiol, Jinju, South Korea

来源：

CANCER INVESTIGATION | 2014年 / 32卷 / 01期

关键词：

Breast cancer; Gene expression; Invasion and metastasis; CIRCULATING TUMOR-CELLS; EXPRESSION; MARKER;

D O I：

10.3109/07357907.2013.861473

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Little is known about the biological role of human mammaglobin (hMAM) that is considered as a promising marker for breast cancer. Here, we investigated hMAM's role related to migration and invasion of human breast cancer cells (hBCC). Compared to normal cells, hBCC have high MAM mRNA expression levels. Of the hBCC tested, MAM mRNA expression levels were higher in noninvasive than in invasive cells. Overexpression of hMAM in breast cancer cells decreased migration and invasion, whereas knockdown of hMAM increased both. Taken together, these results suggest that metastasis of hBCC could be controlled by hMAM expression levels.

引用

页码：22 / 29

页数：8

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