Factor V Leiden and the Risk of Venous Thrombosis, Myocardial Infarction, and Stroke: A Case-Control Study in Venezuela

被引：10

作者：

Pestana, Carolina I. ^{[1
]}

Torres, Argimiro ^{[2
]}

Blanco, Susana ^{[3
]}

Rojas, Maria J. ^{[2
]}

Mendez, Carlos ^{[1
]}

Lopez, Jose L. ^{[2
]}

de Bosch, Norma B. ^{[2
]}

Porco, Antonietta ^{[1
]}

机构：

[1] Univ Simon Bolivar, Dept Biol Celular, Lab Genet Mol Humana B, Caracas 1080 A, Venezuela

[2] Banco Municipal Sangre, Hematol Lab, Caracas, Venezuela

[3] Hosp Dr Miguel Perez Carreno, Unidad Cuidados Coronarios, Caracas, Venezuela

来源：

GENETIC TESTING AND MOLECULAR BIOMARKERS | 2009年 / 13卷 / 04期

关键词：

ACTIVATED PROTEIN-C; POOR ANTICOAGULANT RESPONSE; COAGULATION-FACTOR-V; PROTHROMBIN G20210A; ARTERIAL THROMBOSIS; CANDIDATE GENES; ISCHEMIC-STROKE; APC RESISTANCE; DISEASE RISK; MUTATION;

D O I：

10.1089/gtmb.2008.0100

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The most common genetic defect associated with deep vein thrombosis (DVT) is a mutation in the Factor V gene (G1691A), known as Factor V Leiden (FVL). We investigated the genotypes for FVL in 571 individuals in Venezuela: 208 patients with DVT, 175 patients with acute myocardial infarction, 54 patients with stroke, and 134 control subjects. Our results showed in the population analyzed here that the FVL was associated with a fourfold increase in the risk for DVT (odds ratio, 4.24; 95% confidence interval, 1.35-14.79); particularly, women carriers showed a 6.5-fold increase in the risk for DVT. No relation was observed between the presence of FVL and the risk for acute myocardial infarction or stroke. In conclusion, a clear association between the FVL mutation and DVT was observed in the population analyzed in Venezuela. These results are in agreement with those found in other populations with different ethnic backgrounds.

引用

页码：537 / 542

页数：6

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