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First trimester supratentorial and infratentorial abnormalities in fetuses with open spina bifida
被引:3
作者:
Acuna, Joann
[1
]
Lau, Gregory
[1
]
Rad, Steven
[1
]
Kim, Matthew
[1
]
Gornbein, Jeffrey
[2
]
Zoppi, Maria
[3
]
Monni, Giovanni
[3
]
Rotmensch, Siefried
[1
]
Solt, Ido
[4
]
机构:
[1] Cedars Sinai Med Ctr, Dept Obstet & Gynecol, Los Angeles, CA 90048 USA
[2] Univ Calif Los Angeles, Biomath, Los Angeles, CA USA
[3] Osped Microcitem, Prenatal Diag, Cagliari, Italy
[4] Rambam Hlth Care Campus, IL-3109601 Haifa, Israel
关键词:
First-trimester;
infratentorial;
prenatal diagnosis;
spina bifida;
supratentorial;
CHIARI-II MALFORMATION;
FRONTOMAXILLARY FACIAL ANGLE;
INTRACRANIAL TRANSLUCENCY;
POSTERIOR BRAIN;
VISUALIZATION;
TRISOMY-21;
D O I:
10.1080/14767058.2019.1659772
中图分类号:
R71 [妇产科学];
学科分类号:
100211 ;
摘要:
Objectives: To examine whether supratentorial, infratentorial, and calvarial manifestations of open spina bifida (OSB) occur in the first-trimester. Methods: Supratentorial (midbrain curvature, thalamic height), infratentorial (fourth ventricle diameter, brain-stem diameter [BSD], ratio of BSD to BSD-occipital bone diameter [BSOB]), and calvarial (frontomaxillary facial [FMF] angle) parameters were measured in stored midsagittal facial images at 110-136 weeks of 500 normal and 10 open spina-bifida fetuses by 3 blinded examiners. Results: OSB fetuses displayed a larger midbrain curvature (93.26 +/- 6.97 versus 97.79 +/- 10.04, p < .05), decreased FMF angle (84.10 +/- 5.44 versus 78.46 +/- 5.82, p < .001), smaller fourth ventricle diameter (0.25 +/- 0.04 mm versus 0.18 +/- 0.05 mm, p < .001), smaller BSD (0.29 +/- 0.04 mm versus 0.23 +/- 0.04 mm; p < .001), and increased BSD to BSOB ratio (0.64 +/- 0.71 versus 0.73 +/- 0.93, p < .03) than normal controls, respectively. Thalamic height was not significantly altered. Detection rates of OSB were highest for fourth ventricle diameter and FMF angle (60% and 40%, respectively, at 95% specificity). BSD, BSD to BSOB ratio, midbrain curvature yielded sensitivities of 30% with 95% specificity. Two-dimensional discrimination for pairs of measures combining fourth ventricle diameter with FMF angle increased sensitivity to 90% with specificity of 90.7%. Conclusions: Our findings suggest that supratentorial, infratentorial, and calvarial changes consistent with the Chiari-II malformation are already established in first-trimester fetuses with OSB.
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页码:2159 / 2165
页数:7
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