First trimester supratentorial and infratentorial abnormalities in fetuses with open spina bifida

被引:3
作者
Acuna, Joann [1 ]
Lau, Gregory [1 ]
Rad, Steven [1 ]
Kim, Matthew [1 ]
Gornbein, Jeffrey [2 ]
Zoppi, Maria [3 ]
Monni, Giovanni [3 ]
Rotmensch, Siefried [1 ]
Solt, Ido [4 ]
机构
[1] Cedars Sinai Med Ctr, Dept Obstet & Gynecol, Los Angeles, CA 90048 USA
[2] Univ Calif Los Angeles, Biomath, Los Angeles, CA USA
[3] Osped Microcitem, Prenatal Diag, Cagliari, Italy
[4] Rambam Hlth Care Campus, IL-3109601 Haifa, Israel
关键词
First-trimester; infratentorial; prenatal diagnosis; spina bifida; supratentorial; CHIARI-II MALFORMATION; FRONTOMAXILLARY FACIAL ANGLE; INTRACRANIAL TRANSLUCENCY; POSTERIOR BRAIN; VISUALIZATION; TRISOMY-21;
D O I
10.1080/14767058.2019.1659772
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objectives: To examine whether supratentorial, infratentorial, and calvarial manifestations of open spina bifida (OSB) occur in the first-trimester. Methods: Supratentorial (midbrain curvature, thalamic height), infratentorial (fourth ventricle diameter, brain-stem diameter [BSD], ratio of BSD to BSD-occipital bone diameter [BSOB]), and calvarial (frontomaxillary facial [FMF] angle) parameters were measured in stored midsagittal facial images at 110-136 weeks of 500 normal and 10 open spina-bifida fetuses by 3 blinded examiners. Results: OSB fetuses displayed a larger midbrain curvature (93.26 +/- 6.97 versus 97.79 +/- 10.04, p < .05), decreased FMF angle (84.10 +/- 5.44 versus 78.46 +/- 5.82, p < .001), smaller fourth ventricle diameter (0.25 +/- 0.04 mm versus 0.18 +/- 0.05 mm, p < .001), smaller BSD (0.29 +/- 0.04 mm versus 0.23 +/- 0.04 mm; p < .001), and increased BSD to BSOB ratio (0.64 +/- 0.71 versus 0.73 +/- 0.93, p < .03) than normal controls, respectively. Thalamic height was not significantly altered. Detection rates of OSB were highest for fourth ventricle diameter and FMF angle (60% and 40%, respectively, at 95% specificity). BSD, BSD to BSOB ratio, midbrain curvature yielded sensitivities of 30% with 95% specificity. Two-dimensional discrimination for pairs of measures combining fourth ventricle diameter with FMF angle increased sensitivity to 90% with specificity of 90.7%. Conclusions: Our findings suggest that supratentorial, infratentorial, and calvarial changes consistent with the Chiari-II malformation are already established in first-trimester fetuses with OSB.
引用
收藏
页码:2159 / 2165
页数:7
相关论文
共 18 条
[1]   Intracranial translucency at 11-13 weeks of gestation: prospective evaluation and reproducibility of measurements [J].
Adiego, Begona ;
Illescas, Tamara ;
Martinez-Ten, Pilar ;
Bermejo, Carmina ;
Perez-Pedregosa, Javier ;
Wong, Amy E. ;
Sepulveda, Waldo .
PRENATAL DIAGNOSIS, 2012, 32 (03) :259-263
[2]   Screening for fetal spina bifida by ultrasound examination in the first trimester of pregnancy using fetal biparietal diameter [J].
Bernard, Jean-Pierre ;
Cuckle, Howard S. ;
Stirnemann, Julien J. ;
Salomon, Laurent J. ;
Ville, Yves .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2012, 207 (04) :306.e1-306.e5
[3]   Frontomaxillary facial angle in screening for trisomy 21 at 11+0 to 13+6 weeks [J].
Borenstein, M. ;
Persico, N. ;
Kagan, K. O. ;
Gazzoni, A. ;
Nicolaides, K. H. .
ULTRASOUND IN OBSTETRICS & GYNECOLOGY, 2008, 32 (01) :5-11
[4]   Sonographic diagnosis of spina bifida at 12 weeks: heading towards indirect signs [J].
Buisson, O ;
De Keersmaecker, B ;
Senat, MV ;
Bernard, JP ;
Moscoso, G ;
Ville, Y .
ULTRASOUND IN OBSTETRICS & GYNECOLOGY, 2002, 19 (03) :290-292
[5]   Supratentorial Abnormalities in the Chiari II Malformation, II Tectal Morphologic Changes [J].
Callen, Andrew L. ;
Stengel, Joseph W. ;
Filly, Roy A. .
JOURNAL OF ULTRASOUND IN MEDICINE, 2009, 28 (01) :29-35
[6]   Prospective detection of open spina bifida at 11-13 weeks by assessing intracranial translucency and posterior brain [J].
Chaoui, R. ;
Benoit, B. ;
Heling, K. S. ;
Kagan, K. O. ;
Pietzsch, V. ;
Lopez, A. Sarut ;
Tekesin, I. ;
Karl, K. .
ULTRASOUND IN OBSTETRICS & GYNECOLOGY, 2011, 38 (06) :722-726
[7]   Assessment of intracranial translucency (IT) in the detection of spina bifida at the 11-13-week scan [J].
Chaoui, R. ;
Benoit, B. ;
Mitkowska-Wozniak, H. ;
Heling, K. S. ;
Nicolaides, K. H. .
ULTRASOUND IN OBSTETRICS & GYNECOLOGY, 2009, 34 (03) :249-252
[8]   Retrospective review of diagnostic performance of intracranial translucency in detection of open spina bifida at the 11-13-week scan [J].
Fong, K. W. ;
Toi, A. ;
Okun, N. ;
Al-Shami, E. ;
Menezes, R. J. .
ULTRASOUND IN OBSTETRICS & GYNECOLOGY, 2011, 38 (06) :630-634
[9]   Assessment of the posterior brain at 11-14 weeks for the prediction of open neural tube defects [J].
Kavalakis, Ioannis ;
Souka, Athena P. ;
Pilalis, Athanasios ;
Papastefanou, Ioannis ;
Kassanos, Dimitrios .
PRENATAL DIAGNOSIS, 2012, 32 (12) :1143-1146
[10]   Frontomaxillary facial angle in fetuses with spina bifida at 11-13 weeks' gestation [J].
Lachmann, R. ;
Picciarelli, G. ;
Moratalla, J. ;
Greene, N. ;
Nicolaides, K. H. .
ULTRASOUND IN OBSTETRICS & GYNECOLOGY, 2010, 36 (03) :268-271