Chronic Kidney Disease-Associated Inflammation Increases the Risks of Acute Kidney Injury and Mortality after Cardiac Surgery

被引:11
作者
Casas, Angela [1 ]
Mallen, Adrian [1 ]
Blasco-Lucas, Arnau [2 ]
Sbraga, Fabrizio [2 ]
Guiteras, Jordi [1 ]
Bolanos, Nuria [1 ]
Castano, Esther [3 ]
Torras, Joan [4 ]
Cruzado, Josep M. [4 ]
Navarro, Estanislao [1 ]
Hueso, Miguel [1 ,4 ]
机构
[1] Inst Invest Biomed Bellvitge IDIBELL, Expt Nephrol Lab, Barcelona 08907, Spain
[2] Hosp Univ Bellvitge, Dept Cardiac Surg, Barcelona 08907, Spain
[3] Univ Barcelona, CCiT, Biol Unit, Barcelona 08907, Spain
[4] Hosp Univ Bellvitge, Dept Nephrol, Barcelona 08907, Spain
关键词
chronic kidney disease; cardiac surgery– associated acute kidney injury; coronary artery diseases; inflammation; CD14(++)CD16(+) monocytes; hsa-miR-30a-5p; CARDIOVASCULAR EVENTS; RENAL-DISEASE; MONOCYTES; ATHEROSCLEROSIS; PROGRESSION; CALCIFICATION; DIALYSIS; SUBSETS; FAT;
D O I
10.3390/ijms21249689
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Cardiovascular mortality increases with decreasing renal function although the cause is yet unknown. Here, we have investigated whether low chronic inflammation in chronic kidney diseases (CKD) could contribute to increased risk for coronary artery diseases (CAD). Thus, a prospective case-control study was conducted in patients with CAD and CKD undergoing coronary artery bypass graft surgery with the aim of detecting differences in cardiovascular outcomes, epicardial adipose tissue volume, and inflammatory marker activity associated with renal dysfunction. Expression of membrane CD14 and CD16, inflammatory cytokines and chemokines, mitogen-activated protein (MAP) kinases and hsa-miR-30a-5p were analyzed in peripheral blood mononuclear cells (PBMCs). Epicardial fat volume and tissue inflammation in perivascular adipose tissue and in the aorta were also studied. In the present study, 151 patients were included, 110 with CAD (51 with CKD) and 41 nonCAD controls (15 with CKD). CKD increased the risk of cardiac surgery-associated acute kidney injury (CSA-AKI) as well as the 30-day mortality after cardiac surgery. Higher counts of CD14(++)CD16(+) monocytes were associated with vascular inflammation, with an increased expression of IL1 beta, and with CKD in CAD patients. Expression of hsa-miR-30a-5p was correlated with hypertension. We conclude that CKD patients show an increased risk of CSA-AKI and mortality after cardiovascular surgery, associated with the expansion of the CD14(++)CD16(+) subset of proinflammatory monocytes and with IL1 beta expression. We propose that inflammation associated with CKD may contribute to atherosclerosis (ATH) pathogenesis.
引用
收藏
页码:1 / 15
页数:15
相关论文
共 41 条
[1]   CD14, CD16 and HLA-DR reliably identifies human monocytes and their subsets in the context of pathologically reduced HLA-DR expression by CD14hi/CD16neg monocytes: Expansion of CD14hi/CD16pos and contraction of CD14lo/CD16pos monocytes in acute liver failure [J].
Abeles, Daniel ;
McPhail, Mark J. ;
Sowter, David ;
Antoniades, Charalambos G. ;
Vergis, Nikhil ;
Vijay, Godhev K. Manakkat ;
Xystrakis, Emmanuel ;
Khamri, Wafa ;
Shawcross, Debbie L. ;
Ma, Yun ;
Wendon, Julia A. ;
Vergani, Diego .
CYTOMETRY PART A, 2012, 81A (10) :823-834
[2]   Chronic kidney disease after acute kidney injury: a systematic review and meta-analysis [J].
Coca, Steven G. ;
Singanamala, Swathi ;
Parikh, Chirag R. .
KIDNEY INTERNATIONAL, 2012, 81 (05) :442-448
[3]   Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization [J].
Go, AS ;
Chertow, GM ;
Fan, DJ ;
McCulloch, CE ;
Hsu, CY .
NEW ENGLAND JOURNAL OF MEDICINE, 2004, 351 (13) :1296-1305
[4]   AKI on CKD: heightened injury, suppressed repair, and the underlying mechanisms [J].
He, Liyu ;
Wei, Qingqing ;
Liu, Jing ;
Yi, Mixuan ;
Liu, Yu ;
Liu, Hong ;
Sun, Lin ;
Peng, Youming ;
Liu, Fuyou ;
Venkatachalam, Manjeri A. ;
Dong, Zheng .
KIDNEY INTERNATIONAL, 2017, 92 (05) :1071-1083
[5]   CD14++ CD16+ monocytes but not total monocyte numbers predict cardiovascular events in dialysis patients [J].
Heine, G. H. ;
Ulrich, C. ;
Seibert, E. ;
Seiler, S. ;
Marell, J. ;
Reichart, B. ;
Krause, M. ;
Schlitt, A. ;
Koehler, H. ;
Girndt, M. .
KIDNEY INTERNATIONAL, 2008, 73 (05) :622-629
[6]   Phenotypic characterization of human intermediate monocytes [J].
Hijdra, Danielle ;
Vorselaars, Adriane D. M. ;
Grutters, Jan C. ;
Claessen, Anke M. E. ;
Riikers, Ger T. .
FRONTIERS IN IMMUNOLOGY, 2013, 4
[7]   The double edge of anti-CD40 siRNA therapy: It increases renal microcapillar density but favours the generation of an inflammatory milieu in the kidneys of ApoE-/- mice [J].
Hueso, Miguel ;
Casas, Angela ;
Mallen, Adrian ;
de Ramon, Laura ;
Bolanos, Nuria ;
Varela, Cristian ;
Cruzado, Josep M. ;
Torras, Joan ;
Navarro, Estanislao .
JOURNAL OF INFLAMMATION-LONDON, 2019, 16 (01)
[8]   Silencing of CD40 in vivo reduces progression of experimental atherogenesis through an NF-κB/miR-125b axis and reveals new potential mediators in the pathogenesis of atherosclerosis [J].
Hueso, Miguel ;
De Ramon, Laura ;
Navarro, Estanislao ;
Ripoll, Elia ;
Cruzado, Josep M. ;
Grinyo, Josep M. ;
Torras, Joan .
ATHEROSCLEROSIS, 2016, 255 :80-89
[9]   Chronic Kidney Disease is associated with an increase of Intimal Dendritic cells in a comparative autopsy study [J].
Hueso, Miguel ;
Torras, Joan ;
Carrera, Marta ;
Vidal, August ;
Navarro, Estanis ;
Grinyo, Josep .
JOURNAL OF INFLAMMATION-LONDON, 2015, 12
[10]   A Meta-analysis of the Association of Estimated GFR, Albuminuria, Diabetes Mellitus, and Hypertension With Acute Kidney Injury [J].
James, Matthew T. ;
Grams, Morgan E. ;
Woodward, Mark ;
Elley, C. Raina ;
Green, Jamie A. ;
Wheeler, David C. ;
de Jong, Paul ;
Gansevoort, Ron T. ;
Levey, Andrew S. ;
Warnock, David G. ;
Sarnak, Mark J. .
AMERICAN JOURNAL OF KIDNEY DISEASES, 2015, 66 (04) :602-612