Nickel-Catalyzed Oxidative Cyclotrimerization of α-Amino Ketones: Selective Synthesis of Pyrazoles

被引：3

作者：

Tang, Ri-Yuan ^{[1
,2
]}

Guo, Xiao-Kang ^{[2
]}

Hu, Ming ^{[1
]}

Wang, Zhi-Qiang ^{[1
]}

Xiang, Jian-Nan ^{[1
]}

Li, Jin-Heng ^{[1
]}

机构：

[1] Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Hunan, Peoples R China

[2] Wenzhou Univ, Coll Chem & Mat Engn, Wenzhou 325035, Peoples R China

来源：

SYNLETT | 2014年 / 25卷 / 01期

关键词：

nickel; oxidation; cyclotrimerization; alpha-amino ketones; pyrazoles; FULLY SUBSTITUTED PYRAZOLES; N BOND-FORMATION; REGIOSELECTIVE SYNTHESIS; ONE-POT; 3-COMPONENT SYNTHESIS; EFFICIENT SYNTHESIS; HETEROCYCLES; ARYLATION; LIGANDS; DERIVATIVES;

D O I：

10.1055/s-0033-1340014

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new strategy for the synthesis of 3-methylene-2,3-dihydro-1H-pyrazoles is presented by Ni-catalyzed oxidative cyclotrimerization of -amino ketones. This unprecedented method allows three -amino ketones to undergo sequential multiple deprotonations and deamination through two C-C bonds and one N-N bond formation cascade.

引用

页码：64 / 68

页数：5

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