Amphiphilic Copolymers Capable of Concomitant Release of HNO and Small Molecule Organics

被引：8

作者：

Church, Derek C. ^{[1
]}

Nourian, Saghar ^{[2
]}

Lee, Chang-Uk ^{[1
]}

Yakelis, Neal A. ^{[3
]}

Toscana, John P. ^{[2
]}

Boydston, Andrew J. ^{[1
]}

机构：

[1] Univ Washington, Dept Chem, Seattle, WA 98195 USA

[2] Johns Hopkins Univ, Dept Chem, Charles & 34th St, Baltimore, MD 21218 USA

[3] Pacific Lutheran Univ, Dept Chem, Tacoma, WA 98447 USA

来源：

ACS MACRO LETTERS | 2017年 / 6卷 / 01期

基金：

美国国家科学基金会;

关键词：

NITROXYL HNO;

D O I：

10.1021/acsmacrolett.6b00887

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

We demonstrate concomitant release of HNO and small molecule organics from amphiphilic poly-(norbornene)-based copolymers. This key function was achieved by incorporation of thermally labile oxazine units within random and block copolymer architectures. Upon thermolysis, we observed generation of HNO and release of a small molecule conjugate. Importantly, the release kinetics of HNO and a UV-active small molecule (4-nitroaniline) were found to be 1:1, signifying an ability to monitor HNO production indirectly, or to simultaneously release organic therapeutics (es, nonsteroidal anti-inflammatory drugs) along with HNO. To our knowledge, these are the first reported polymeric materials demonstrating HNO release from covalently attached HNO donors.

引用

页码：46 / 49

页数：4

共 31 条

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