Chitooligosaccharides for wound healing biomaterials engineering

被引：53

作者：

Jafari, Hafez ^{[1
]}

Bernaerts, Katrien, V ^{[2
]}

Dodi, Gianina ^{[3
]}

Shavandi, Amin ^{[1
]}

机构：

[1] Univ Libre Bruxelles, BioMatter Biomass Transformat Lab BTL, Ecole Polytech Bruxelles, Ave FD Roosevelt 50 CP 165-61, B-1050 Brussels, Belgium

[2] Maastricht Univ, Aachen Maastricht Inst Biobased Mat AMIBM, Brightlands Chemelot Campus,Urmonderbaan 22, NL-6167 RD Geleen, Netherlands

[3] Grigore T Popa Univ Med & Pharm Iasi, Adv Ctr Res Dev Expt Med, Iasi 700115, Romania

来源：

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2020年 / 117卷

关键词：

Chitooligosaccharide; Physicochemical properties; Antibacterial and antifungal; Antioxidant; Anti-inflammatory; Immunostimulatory; Wound healing; in vitro and in vivo studies; RADICAL SCAVENGING ACTIVITY; OXIDIZED CHITOSAN OLIGOSACCHARIDE; MOLECULAR-WEIGHT CHITOSANS; WATER-SOLUBLE CHITOSAN; BIOLOGICAL-ACTIVITIES; ANTIBACTERIAL ACTIVITY; ANTIOXIDANT ACTIVITY; OXIDATIVE STRESS; NITRIC-OXIDE; PHYSICOCHEMICAL CHARACTERISTICS;

D O I：

10.1016/j.msec.2020.111266

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Chitooligosaccharides (CHOS) are oligomers of beta-(1-4) linked N-acetylglucosamine and D-glucosamine that are produced from chitin or chitosan using different enzymatic or chemical methods. CHOS are water-soluble and non-cytotoxic with diverse bioactivities such as antibacterial, anti-inflammation, anti-obesity, anti-tumor and antioxidant. These biological features make CHOS promising compounds for several medical and food applications. In this review, we critically summarize the biological activities of CHOS in biomaterials engineering with a particular focus on CHOS applications for skin tissue healing and regeneration. We also present an updated overview of CHOS fabrications into wound dressing biomaterials for several in vitro and in vivo studies.

引用

页数：17

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