Epstein-Barr virus associated B-cell lymphoma after autologous bone marrow transplantation for T-cell acute lymphoblastic leukaemia

被引：27

作者：

Briz, M ^{[1
]}

Fores, R ^{[1
]}

Regidor, C ^{[1
]}

Busto, MJ ^{[1
]}

Cajal, SRY ^{[1
]}

Cabrera, R ^{[1
]}

Diez, JL ^{[1
]}

Sanjuan, I ^{[1
]}

Fernandez, MN ^{[1
]}

机构：

[1] UNIV AUTONOMA MADRID,HOSP PUERTA HIERRO,DEPT PATHOL,MADRID 28035,SPAIN

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1997年 / 98卷 / 02期

关键词：

bone marrow transplantation; bone marrow purging; human herpesvirus 4; acute T-cell leukaemia; non-Hodgkin's lymphoma;

D O I：

10.1046/j.1365-2141.1997.2153034.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Epstein-Barr virus associated lymphoproliferative disease after autologous bone marrow transplantation (ABMT) has rarely been reported. We report a case of B-cell lymphoma following ABMT for T-acute lymphoblastic leukaemia: bone marrow was purged in vitro with monoclonal antibodies to remove T cells. Immunoglobulin and T-cell receptor gene rearrangement studies were used to demonstrate clonality and to show that this patient developed a second neoplasm after ABMT. EBV proteins and genome (type A) were present in post-transplantation lymphoma, suggesting a causative role in its development.

引用

页码：485 / 487

页数：3

共 12 条

[1] Malignant neoplasms following bone marrow transplantation [J].

Bhatia, S ;

Ramsay, NKC ;

Steinbuch, M ;

Dusenbery, KE ;

Shapiro, RS ;

Weisdorf, DJ ;

Robison, LL ;

Miller, JS ;

Neglia, JP .

BLOOD, 1996, 87 (09) :3633-3639

[2]

Caldas Carlos, 1995, Current Opinion in Oncology, V7, P102, DOI 10.1097/00001622-199503000-00002

[3]

CHAO NJ, 1993, TRANSPLANTATION, V55, P1425

[4] POSTTRANSPLANTATION LYMPHOPROLIFERATIVE DISORDERS FREQUENTLY CONTAIN TYPE-A AND NOT TYPE-B EPSTEIN-BARR-VIRUS [J].

FRANK, D ;

CESARMAN, E ;

LIU, YF ;

MICHLER, RE ;

KNOWLES, DM .

BLOOD, 1995, 85 (05) :1396-1403

[5]

KNOWLES DM, 1995, BLOOD, V85, P552

[6] INFUSIONS OF DONOR LEUKOCYTES TO TREAT EPSTEIN-BARR VIRUS-ASSOCIATED LYMPHOPROLIFERATIVE DISORDERS AFTER ALLOGENEIC BONE-MARROW TRANSPLANTATION [J].

PAPADOPOULOS, EB ;

LADANYI, M ;

EMANUEL, D ;

MACKINNON, S ;

BOULAD, F ;

CARABASI, MH ;

CASTROMALASPINA, H ;

CHILDS, BH ;

GILLIO, AP ;

SMALL, TN ;

YOUNG, JW ;

KERNAN, NA ;

OREILLY, RJ .

NEW ENGLAND JOURNAL OF MEDICINE, 1994, 330 (17) :1185-1191

[7]

RIDDLER SA, 1994, BLOOD, V84, P972

[8] MOLECULAR GENETIC-ANALYSIS OF POSTTRANSPLANT LYMPHOPROLIFERATIVE DISORDERS [J].

SEIDEN, MV ;

SKLAR, J .

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA, 1993, 7 (02) :447-465

[9]

SHAPIRO RS, 1988, BLOOD, V71, P1234

[10]

SHEPHERD JD, 1995, BONE MARROW TRANSPL, V15, P639

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