Epstein-Barr virus associated B-cell lymphoma after autologous bone marrow transplantation for T-cell acute lymphoblastic leukaemia

被引：27

作者：

Briz, M ^{[1
]}

Fores, R ^{[1
]}

Regidor, C ^{[1
]}

Busto, MJ ^{[1
]}

Cajal, SRY ^{[1
]}

Cabrera, R ^{[1
]}

Diez, JL ^{[1
]}

Sanjuan, I ^{[1
]}

Fernandez, MN ^{[1
]}

机构：

[1] UNIV AUTONOMA MADRID,HOSP PUERTA HIERRO,DEPT PATHOL,MADRID 28035,SPAIN

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1997年 / 98卷 / 02期

关键词：

bone marrow transplantation; bone marrow purging; human herpesvirus 4; acute T-cell leukaemia; non-Hodgkin's lymphoma;

D O I：

10.1046/j.1365-2141.1997.2153034.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Epstein-Barr virus associated lymphoproliferative disease after autologous bone marrow transplantation (ABMT) has rarely been reported. We report a case of B-cell lymphoma following ABMT for T-acute lymphoblastic leukaemia: bone marrow was purged in vitro with monoclonal antibodies to remove T cells. Immunoglobulin and T-cell receptor gene rearrangement studies were used to demonstrate clonality and to show that this patient developed a second neoplasm after ABMT. EBV proteins and genome (type A) were present in post-transplantation lymphoma, suggesting a causative role in its development.

引用

页码：485 / 487

页数：3

共 12 条

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