The Effects of Physical Exercise on Plasma Levels of Relaxin, NTproANP, and NTproBNP in Patients with Ischemic Heart Disease

被引：13

作者：

Heringlake, M. ^{[1
]}

Kox, T. ^{[2
]}

Pocling, J. ^{[6
]}

Klaus, S. ^{[3
]}

Hanke, T.

Franz, N. ^{[2
]}

Eberhardt, F.

Heinze, H.

Armbruster, F. P. ^{[4
]}

Bahlmann, L. ^{[5
]}

机构：

[1] Med Univ Lubeck, Anasthesiol Klin, Kliniken Anasthesiol, D-23538 Lubeck, Germany

[2] Kliniken Kardiol, Bad Rothenfelde, Germany

[3] Herz Jesu Krankenhaus, Anasthesiol Klin, Munster, Germany

[4] Immundiagnost AG, Bensheim, Germany

[5] Krankenhaus Weser Egge, Anasthesiol Klin, Hoxter, Germany

[6] Schuchtermann Klin, Bad Rothenfelde, Germany

来源：

EUROPEAN JOURNAL OF MEDICAL RESEARCH | 2009年 / 14卷 / 03期

关键词：

Heart failure; coronary artery disease; cardiorenal integration; natriuretic peptides; hemodynamics; right heart catheterization; PREGNANCY HORMONE RELAXIN; CARDIAC POWER OUTPUT; NATRIURETIC-PEPTIDE; PROGNOSIS; PLAYER;

D O I：

10.1186/2047-783X-14-3-106

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The insulin-like and vasodilatatory polypeptide relaxin (RLA), formerly known as a pregnancy hormome, has gained interest as a potential humora mediator in human heart failure. Controversy exists about the relation between plasma levels of RLX and the severity of heart failure. The present study was designed to determine the course of RLX, atrial, and brain natriuretic peptide (NT-proANP and NT-proBNP) during physical exercise in patients with ischemic heart disease (IHD) and to relate hormone levels to peak cardiac power output (CPO) as a measure of cardiopulmonary function with prognostic relevance. 40 patients with 1HD were studied during right-heart- catheterization at rest and during supine bicycle ergometry. RLX, NT-proBNP, and NTproANP were determined before, during execise, and after recovery. NT-proANP and NT-proBNP levels increased during maximal charge, and recovery while RLX levels decreased. Cardiac power output at maximal charge correlated inversely with NTproANP and NT-proBNP but positively with RLX. Patients with high degree heart failure (CPO<1.96 W) had higher NT-proANP and NT-proBNP and lower RLX levels than patients with low degree heart failure. While confirming the role of NT-proANP and NT-proBNP as markers for the severity of heart failure, the present data do not support the concept that plasma levels of RLX are related to the severity of myocardial dysfunction and that systemic RLX acts as a compensatory vasodilatatory response hormone in ischemic heart disease.

引用

页码：106 / 112

页数：7

共 16 条

[1] Physiological range of peak cardiac power output in healthy adults [J].

Bromley, PD ;

Hodges, LD ;

Brodie, DA .

CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING, 2006, 26 (04) :240-246

[2] Emerging role of relaxin in renal and cardiovascular function [J].

Conrad, KP ;

Novak, J .

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2004, 287 (02) :R250-R261

[3] Myocardial relaxin counteracts hypertrophy in hypertensive rats [J].

Dschietzig, T ;

Bartsch, C ;

Kinkel, T ;

Baumann, G ;

Stangl, K .

RELAXIN AND RELATED PEPTIDES: FOURTH INTERNATIONAL CONFERENCE, 2005, 1041 :441-443

[4] The pregnancy hormone relaxin is a player in human heart failure [J].

Dschietzig, T ;

Richter, C ;

Bartsch, C ;

Laule, M ;

Armbruster, FP ;

Baumann, G ;

Stangl, K .

FASEB JOURNAL, 2001, 15 (12) :2187-2195

[5] N-terminal pro B type natriuretic peptide, but not the new putative cardiac hormone relaxin, predicts prognosis in patients with chronic heart failure [J].

Fisher, C ;

Berry, C ;

Blue, L ;

Morton, JJ ;

McMurray, J .

HEART, 2003, 89 (08) :879-881

[6] Is the pregnancy hormone relaxin also a vasodilator peptide secreted by the heart? [J].

Fisher, C ;

MacLean, M ;

Morecroft, I ;

Seed, A ;

Johnston, F ;

Hillier, C ;

McMurray, J .

CIRCULATION, 2002, 106 (03) :292-295

[7] Effects of tilting and volume loading on plasma levels and urinary excretion of relaxin, NT-pro-ANP, and NT-pro-BNP in male volunteers [J].

Heringlake, M ;

Heide, C ;

Bahlmann, L ;

Eichler, W ;

Pagel, H ;

Schmucker, P ;

Wergeland, R ;

Armbruster, FP ;

Klaus, S .

JOURNAL OF APPLIED PHYSIOLOGY, 2004, 97 (01) :173-179

[8] Augmented response in plasma atrial natriuretic peptide to dynamic exercise in patients with congestive heart failure [J].

Kato, M ;

Kinugawa, T ;

Omodani, H ;

Osaki, S ;

Ogino, K ;

Hisatome, I ;

Miyakoda, H ;

Fujimoto, Y .

JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION, 1996, 60 (12) :909-916

[9]

Kruger Stefan, 2004, Eur J Intern Med, V15, P54, DOI 10.1016/j.ejim.2003.11.009

[10] Is the pregnancy hormone relaxin an important player in human heart failure? [J].

Kupari, M ;

Mikkola, TS ;

Turto, H ;

Lommi, J .

EUROPEAN JOURNAL OF HEART FAILURE, 2005, 7 (02) :195-198

← 1 2 →