Effectiveness of 13-Valent Pneumococcal Conjugate Vaccine Against Invasive Disease Caused by Serotype 3 in Children: A Systematic Review and Meta-analysis of Observational Studies

被引：87

作者：

Sings, Heather L. ^{[1
]}

De Wals, Philippe ^{[2
]}

Gessner, Bradford D. ^{[1
]}

Isturiz, Raul ^{[1
]}

Laferriere, Craig ^{[3
]}

McLaughlin, John M. ^{[1
]}

Pelton, Stephen ^{[4
,5
,6
]}

Schmitt, Heinz-Josef ^{[7
]}

Suaya, Jose A. ^{[8
]}

Jodar, Luis ^{[1
]}

机构：

[1] Pfizer Inc, Vaccines Med Dev & Sci & Clin Affairs, Collegeville, PA USA

[2] Laval Univ, Dept Social & Prevent Med, Quebec City, PQ, Canada

[3] Pfizer Canada Inc, Vaccines Med Dev & Sci & Clin Affairs, Kirkland, PQ, Canada

[4] Boston Univ, Sch Med, Boston, MA 02215 USA

[5] Boston Univ, Sch Publ Hlth, Boston, MA 02215 USA

[6] Boston Med Ctr, Boston, MA USA

[7] Pfizer Inc, Vaccines Med Dev & Sci & Clin Affairs, Paris, France

[8] Pfizer Inc, Vaccines Med Dev & Sci & Clin Affairs, New York, NY USA

来源：

CLINICAL INFECTIOUS DISEASES | 2019年 / 68卷 / 12期

关键词：

pneumococcal conjugate vaccine; serotype; 3; meta-analysis; CARRIAGE; ENGLAND; IMPACT; WALES; PCV13;

D O I：

10.1093/cid/ciy920

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The 13-valent pneumococcal conjugate vaccine (PCV13) is the only licensed PCV with serotype 3 polysaccharide in its formulation. Postlicensure PCV13 effectiveness studies against serotype 3 invasive pneumococcal disease (IPD) in children have shown inconsistent results. We performed a systematic review and meta-analysis of observational studies to assess PCV13 vaccine effectiveness (VE) for serotype 3 IPD in children. We systematically searched PubMed, Embase, and the Cochrane library for studies published before 14 August 2017. We identified 4 published studies and 2 conference posters that provided PCV13 VE estimates stratified by serotype. The pooled PCV13 VE against serotype 3 IPD from the random-effects meta-analysis was 63.5% (95% confidence interval [CI], 37.3%-89.7%). A sensitivity analysis including conference posters gave a pooled VE estimate of 72.4% (95% CI, 56.7%-88.0%). The pooled data from case-control studies with similar methodologies and high quality support direct PCV13 protection against serotype 3 IPD in children.

引用

页码：2135 / 2143

页数：9

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