Dispersion of Single Walled Carbon Nanotubes in Marine Polysaccharides for Bone Tissue Engineering

被引：9
作者：
Venkatesan, Jayachandran [1 ,2 ]
Pallela, Ramjee [3 ]
Kim, Se-Kwon [1 ,2 ]
机构：
[1] Pukyong Natl Univ, Dept Marine Bio Convergence Sci, Pusan 608737, South Korea
[2] Pukyong Natl Univ, Marine Bioproc Res Ctr, Pusan 608737, South Korea
[3] Int Ctr Genet Engn & Biotechnol, Synthet Biol & Biofuels Grp, New Delhi 110067, India
来源：
JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING | 2014年 / 4卷 / 06期
关键词：
Single Walled Carbon Nanotube; Chitosan; Alginate; Bone Tissue Engineering; COMPOSITE SCAFFOLDS; IN-VITRO; BIOMEDICAL APPLICATIONS; CHITOSAN; ALGINATE; SPONGE;
D O I：
10.1166/jbt.2014.1187
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Tissue engineering is an emerging interdisciplinary field of research and gained much attention in the recent years to produce artificial organs. In the present study, chitosan-alginate (Chi-Alg) and chitosan-alginate with single walled carbon nanotubes (Chi-Alg-SWNT) scaffolds were fabricated by freeze-drying method and physicochemically characterized as bone graft substitutes. The water uptake and retention ability of composite scaffolds (Chi-Alg and Chi-Alg-SWNT) showed similar efficiency. The porosity and pore size of Chi-Alg-SWNT scaffold was found to be greater than 90% and 58-459 mu m, respectively. Cell viability, alkaline phosphatase activity and mineralization of the scaffolds were checked in vitro using MG63 cell line and the results revealed that Chi-Alg-SWNT scaffold system has better activity compared to Chi-Alg system. The observations suggest that Chi-Alg-SWNT composite scaffold is one of the promising biomaterials for bone tissue engineering.
引用
收藏
页码：501 / 505
页数：5
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