A challenge for miRNA: multiple isomiRs in miRNAomics

被引：87
作者：
Guo, Li [1 ]
Chen, Feng [1 ]
机构：
[1] Nanjing Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Nanjing 211166, Jiangsu, Peoples R China
来源：
GENE | 2014年 / 544卷 / 01期
基金：
高等学校博士学科点专项科研基金; 中国博士后科学基金; 中国国家自然科学基金;
关键词：
MicroRNA (miRNA); IsomiR; Expression pattern; Evolutionary pattern; SMALL RNA; DROSHA-DGCR8; COMPLEX; MICRORNA REPERTOIRE; ADDITION EVENTS; SEQUENCING DATA; 3' ADENYLATION; EXPRESSION; EVOLUTION; CLUSTERS; GENES;
D O I：
10.1016/j.gene.2014.04.039
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Accumulating evidence suggests that a single microRNA (miRNA) locus can generate a series of sequences during miRNA maturation process. These multiple sequences, called miRNA variants, or isomiRs, have different lengths and different 5' and 3' ends. Some of these isomiRs are detected as varied nucleotides and 3' additional non-template nucleotides. As physiological miRNA isoforms, they have drawn attention for possible regulatory biological roles. The present work mainly reviews miRNA/isomiR biogenesis, isomiR expression patterns, and functional and evolutionary implications, especially between isomiRs from homologous and clustered miRNA loci. The phenomenon of multiple isomiRs and their biological roles indicates that analysis performed at the miRNA and isomiR levels should be included in miRNA studies. This may enrich and complicate miRNA biogenesis and coding-non-coding RNA regulatory networks. (C) 2014 Elsevier B.V. All rights reserved.
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页码：1 / 7
页数：7
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