Weakly Anti-inflammatory Limonoids from the Seeds of Xylocarpus rumphii

被引：27
|
作者：
Sarigaputi, Chanin [1 ]
Sommit, Damrong [3 ]
Teerawatananond, Thapong [2 ]
Pudhom, Khanitha [2 ]
机构：
[1] Chulalongkorn Univ, Fac Sci, Program Biotechnol, Bangkok 10330, Thailand
[2] Chulalongkorn Univ, Fac Sci, Dept Chem, Bangkok 10330, Thailand
[3] Mahanakorn Univ, Dept Chem, Fac Sci, Bangkok 10530, Thailand
来源：
JOURNAL OF NATURAL PRODUCTS | 2014年 / 77卷 / 09期
关键词：
CHINESE MANGROVE; GRANATUM; MOLUCCENSIS;
D O I：
10.1021/np5003687
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Seven new limonoids, namely, xylorumphiins EJ (1-2 and 4-7) and 2-hydroxyxylorumphiin F (3), along with three known derivatives (810), were isolated from the seeds of Xylocarpus rumphii. 2-Hydroxyxylorumphiin F (3) and xylorumphiin I (6) displayed moderate inhibitory activity against nitric oxide production from lipopolysaccharide-activated macrophages with IC50 values of 24.5 and 31.3 mu M, respectively.
引用
收藏
页码：2037 / 2043
页数：7
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