PdII-Catalyzed Mild C-H ortho Arylation and Intramolecular Animation Oriented by a Phosphinamide Group

被引：43

作者：

Guan, Jing ^{[1
,2
]}

Wu, Guo-Jie ^{[3
]}

Han, Fu-She ^{[1
,4
]}

机构：

[1] Chinese Acad Sci, Changchun Inst Appl Chem, Changchun 130022, Jilin, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 100864, Peoples R China

[3] NE Normal Univ, Dept Chem, Changchun 130024, Jilin, Peoples R China

[4] Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116024, Peoples R China

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2014年 / 20卷 / 12期

关键词：

amination; arylation; CH functionalization; palladium; phosphinamide; CROSS-COUPLING REACTIONS; ARYL HYDROGEN PHOSPHATES; BOND FORMATION; PALLADIUM; COPPER; ACTIVATION; PHOSPHITES; ACIDS; PHOSPHONATION; CONSTRUCTION;

D O I：

10.1002/chem.201303056

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel protocol for the Pd-catalyzed ortho-arylation of aryl phosphinamide with boronic acid is reported. By using phosphinamide as a new directing group, the reaction proceeds efficiently under mild conditions at 40 degrees C. Mechanistic studies reveal that the reaction proceeds via a Pd-II to Pd-0 cycle. The phosphinamide group is also shown to be an effective orienting group for direct CH amination.

引用

页码：3301 / 3305

页数：5

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