Integrating Hebbian and homeostatic plasticity: the current state of the field and future research directions

被引：121

作者：

Keck, Tara ^{[1
]}

Toyoizumi, Taro ^{[2
]}

Chen, Lu ^{[3
]}

Doiron, Brent ^{[4
]}

Feldman, Daniel E. ^{[5
]}

Fox, Kevin ^{[6
]}

Gerstner, Wulfram ^{[7
]}

Haydon, Philip G. ^{[8
]}

Huebener, Mark ^{[9
]}

Lee, Hey-Kyoung ^{[10
]}

Lisman, John E. ^{[11
]}

Rose, Tobias ^{[9
]}

Sengpiel, Frank ^{[1
,6
]}

Stellwagen, David ^{[12
]}

Stryker, Michael P. ^{[13
]}

Turrigiano, Gina G. ^{[11
]}

van Rossum, Mark C. ^{[14
]}

机构：

[1] UCL, Dept Neurosci Physiol & Pharmacol, London, England

[2] RIKEN, Brain Sci Inst, Wako, Saitama, Japan

[3] Stanford Univ, Dept Neurosurg, Stanford, CA 94305 USA

[4] Univ Pittsburgh, Dept Math, Pittsburgh, PA USA

[5] Univ Calif Berkeley, Dept Mol & Cell Biol, 229 Stanley Hall, Berkeley, CA 94720 USA

[6] Cardiff Univ, Div Neurosci, Cardiff, S Glam, Wales

[7] Ecole Polytech Fed Lausanne, Brain Mind Inst, Lausanne, Switzerland

[8] Tufts Univ, Sch Med, Medford, MA 02155 USA

[9] Max Planck Inst Neurobiol, Dept Cellular & Syst Neurosci, Martinsried, Bayern, Germany

[10] Johns Hopkins Univ, Zanvyl Krieger Mind Brain Inst, Baltimore, MD USA

[11] Brandeis Univ, Dept Biol, Waltham, MA 02254 USA

[12] McGill Univ, Ctr Res Neurosci, Montreal, PQ, Canada

[13] Univ Calif San Francisco, Sandler Neurosci Ctr, San Francisco, CA 94143 USA

[14] Univ Edinburgh, Sch Informat, Edinburgh, Midlothian, Scotland

来源：

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES | 2017年 / 372卷 / 1715期

基金：

英国医学研究理事会; 美国国家科学基金会; 英国生物技术与生命科学研究理事会;

关键词：

Hebbian plasticity; homeostatic mechanisms; theoretical modelling; COMPARTMENTALIZED DENDRITIC PLASTICITY; INHIBITORY SYNAPTIC-TRANSMISSION; CRITICAL-PERIOD PLASTICITY; FIRING RATE HOMEOSTASIS; ADULT-BORN NEURONS; DEPENDENT PLASTICITY; VISUAL-CORTEX; MONOCULAR DEPRIVATION; NETWORK HOMEOSTASIS; STRUCTURAL BASIS;

D O I：

10.1098/rstb.2016.0158

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We summarize here the results presented and subsequent discussion from the meeting on Integrating Hebbian and Homeostatic Plasticity at the Royal Society in April 2016. We first outline the major themes and results presented at the meeting. We next provide a synopsis of the outstanding questions that emerged from the discussion at the end of the meeting and finally suggest potential directions of research that we believe are most promising to develop an understanding of how these two forms of plasticity interact to facilitate functional changes in the brain. This article is part of the themed issue 'Integrating Hebbian and homeostatic plasticity'.

引用

页数：8

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