Estimation of patient sensitivity to drug effect during Propofol hypnosis

被引：25

作者：

De Keyser, Robin ^{[1
]}

Copot, Dana ^{[1
]}

Ionescu, Clara ^{[1
]}

机构：

[1] Univ Ghent, Fac Engn & Architecture, Dept Elect Energy Syst & Automat, B-9000 Ghent, Belgium

来源：

2015 IEEE INTERNATIONAL CONFERENCE ON SYSTEMS, MAN, AND CYBERNETICS (SMC 2015): BIG DATA ANALYTICS FOR HUMAN-CENTRIC SYSTEMS | 2015年

关键词：

model-based control; anesthesia modeling; drug delivery systems; personalized healthcare; CLOSED-LOOP CONTROL; BISPECTRAL INDEX; PERFORMANCE ASSESSMENT; ANESTHESIA; REMIFENTANIL;

D O I：

10.1109/SMC.2015.435

中图分类号：

TP3 [计算技术、计算机技术];

学科分类号：

0812 ;

摘要：

In this paper we introduce a methodology for adapting a population model to the actual patient dynamics, i.e. an individualization of target controlled infusion (TCI) based infusion. The solution proposed in this paper is to use the effect site concentration (Ce) of the drug into the patient as a feedback signal and to adapt the parameters of the Hill curve (relating the BIS and Ce) during the induction phase, resulting in a patient-individualized closed loop control of anesthesia. This allows moving from conventional generic patient models for drug infusion regulatory loops to personalized medicine.

引用

页码：2487 / 2491

页数：5

共 23 条

[1]

Absalom A.R., 2002, ANAESTHESIA, V57

[2] Closed-loop control of propofol anaesthesia using bispectral index™:: performance assessment in patients receiving computer-controlled propofol and manually controlled remifentanil infusions for minor surgery [J].

Absalom, AR ;

Kenny, GNC .

BRITISH JOURNAL OF ANAESTHESIA, 2003, 90 (06) :737-741

[3] Closed-loop control of anesthesia using bispectral index - Performance assessment in patients undergoing major orthopedic surgey under combined general and regional anesthesia [J].

Absalom, AR ;

Sutcliffe, N ;

Kenny, GN .

ANESTHESIOLOGY, 2002, 96 (01) :67-73

[4]

[Anonymous], CLIN PHARMACOKINETIC

[5] Robust control of depth of anesthesia [J].

Dumont, Guy A. ;

Martinez, Arturo ;

Ansermino, J. Mark .

INTERNATIONAL JOURNAL OF ADAPTIVE CONTROL AND SIGNAL PROCESSING, 2009, 23 (05) :435-454

[6]

Furutani E., 2005, P 2005 IEEE C CONTR

[7]

Ionescu C., 2014, J CLIN MONIT COMPUT, V28, P537

[8] Nonlinear dynamics of the patient's response to drug effect during general anesthesia [J].

Ionescu, Clara ;

Machado, Jose Tenreiro ;

De Keyser, Robin ;

Decruyenaere, Johan ;

Struys, Michel M. R. F. .

COMMUNICATIONS IN NONLINEAR SCIENCE AND NUMERICAL SIMULATION, 2015, 20 (03) :914-926

[9] Robust predictive control strategy applied for propofol dosing using BIS as a controlled variable during anesthesia [J].

Ionescu, Clara M. ;

De Keyser, Robin ;

Torrico, Bismark Claure ;

De Smet, Tom ;

Struys, Michel M. R. F. ;

Normey-Rico, Julio E. .

IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 2008, 55 (09) :2161-2170

[10] Variable Time-Delay Estimation for Anesthesia Control During Intensive Care [J].

Ionescu, Clara M. ;

Hodrea, Ramona ;

De Keyser, Robin .

IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 2011, 58 (02) :363-369

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