New Insights Into Implications of CTRP3 in Obesity, Metabolic Dysfunction, and Cardiovascular Diseases: Potential of Therapeutic Interventions

被引：29

作者：

Guo, Bei ^{[1
,2
]}

Zhuang, Tongtian ^{[3
]}

Xu, Feng ^{[1
,2
]}

Lin, Xiao ^{[4
]}

Li, Fuxingzi ^{[1
,2
]}

Shan, Su-Kang ^{[1
,2
]}

Wu, Feng ^{[5
]}

Zhong, Jia-Yu ^{[1
,2
]}

Wang, Yi ^{[1
,2
]}

Zheng, Ming-Hui ^{[1
,2
]}

Xu, Qiu-Shuang ^{[1
,2
]}

Ehsan, Ullah Muhammad Hasnain ^{[1
,2
]}

Yuan, Ling-Qing ^{[1
,2
]}

机构：

[1] Cent South Univ, Natl Clin Res Ctr Metab Dis, Hunan Prov Key Lab Metab Bone Dis, Xiangya Hosp 2, Changsha, Peoples R China

[2] Cent South Univ, Xiangya Hosp 2, Dept Endocrinol & Metab, Changsha, Peoples R China

[3] Fourth Mil Med Univ, Xijing Hosp, Dept Dermatol, Xian, Peoples R China

[4] Cent South Univ, Dept Radiol, Xiangya Hosp 2, Changsha, Peoples R China

[5] Cent South Univ, Dept Pathol, Xiangya Hosp 2, Changsha, Peoples R China

来源：

FRONTIERS IN PHYSIOLOGY | 2020年 / 11卷

基金：

中国国家自然科学基金;

关键词：

adipocytokines; CTRP3; insulin resistance; therapeutic targets; type 2 diabetes mellitus; obesity; metabolic syndrome; cardiovascular disorders; FACTOR-RELATED PROTEIN-3; REPEAT-CONTAINING SEQUENCE; MUSCLE-CELL CALCIFICATION; C1Q/TNF-RELATED PROTEIN-3; ADIPOSE-TISSUE; COLLAGENOUS REPEAT; OXIDATIVE STRESS; ADIPONECTIN MULTIMERIZATION; CHROMOSOMAL LOCALIZATION; PROMOTES PROLIFERATION;

D O I：

10.3389/fphys.2020.570270

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Adipose tissue, as the largest endocrine organ, secretes many biologically active molecules circulating in the bloodstream, collectively termed adipocytokines, which not only regulate the metabolism but also play a role in pathophysiological processes. C1q tumor necrosis factor (TNF)-related protein 3 (CTRP3) is a member of C1q tumor necrosis factor-related proteins (CTRPs), which is a paralog of adiponectin. CTRP3 has a wide range of effects on glucose/lipid metabolism, inflammation, and contributes to cardiovascular protection. In this review, we comprehensively discussed the latest research on CTRP3 in obesity, diabetes, metabolic syndrome, and cardiovascular diseases.

引用

页数：11

共 113 条

[11] A designed TLR4/MD-2 complex to capture LPS [J].

Brandl, K ;

Glück, T ;

Hartmann, P ;

Salzberger, B ;

Falk, W .

JOURNAL OF ENDOTOXIN RESEARCH, 2005, 11 (04) :197-206

[12] CTRP3 Alleviates Ox-LDL-Induced Inflammatory Response and Endothelial Dysfunction in Mouse Aortic Endothelial Cells by Activating the PI3K/Akt/eNOS Pathway [J].

Chen, Lei ;

Qin, Lijun ;

Liu, Xin ;

Meng, Xiangyun .

INFLAMMATION, 2019, 42 (04) :1350-1359

[13] Control of glucose uptake and release by the liver in vivo [J].

Cherrington, AD .

DIABETES, 1999, 48 (05) :1198-1214

[14] IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045 [J].

Cho, N. H. ;

Shaw, J. E. ;

Karuranga, S. ;

Huang, Y. ;

Fernandes, J. D. da Rocha ;

Ohlrogge, A. W. ;

Malanda, B. .

DIABETES RESEARCH AND CLINICAL PRACTICE, 2018, 138 :271-281

[15] Effects of a Combined Aerobic and Resistance Exercise Program on C1q/TNF-Related Protein-3 (CTRP-3) and CTRP-5 Levels [J].

Choi, Hae Yoon ;

Park, Ji Woo ;

Lee, Namseok ;

Hwang, Soon Young ;

Cho, Geum Ju ;

Hong, Ho Cheol ;

Yoo, Hye Jin ;

Hwang, Taek Geun ;

Kim, Seon Mi ;

Baik, Sei Hyun ;

Park, Kyong Soo ;

Youn, Byung-Soo ;

Choi, Kyung Mook .

DIABETES CARE, 2013, 36 (10) :3321-3327

[16] Implications of C1q/TNF-related protein-3 (CTRP-3) and progranulin in patients with acute coronary syndrome and stable angina pectoris [J].

Choi, Kyung Mook ;

Hwang, Soon Young ;

Hong, Ho Chel ;

Choi, Hae Yoon ;

Yoo, Hye Jin ;

Youn, Byung-Soo ;

Baik, Sei Hyun ;

Seo, Hong Seog .

CARDIOVASCULAR DIABETOLOGY, 2014, 13

[17] C1q/TNF-Related Protein-3 (CTRP-3) and Pigment Epithelium-Derived Factor (PEDF) Concentrations in Patients With Type 2 Diabetes and Metabolic Syndrome [J].

Choi, Kyung Mook ;

Hwang, Soon Young ;

Hong, Ho Cheol ;

Yang, Sae Jeong ;

Choi, Hae Yoon ;

Yoo, Hye Jin ;

Lee, Kwan Woo ;

Nam, Moon Suk ;

Park, Yong Soo ;

Woo, Jeong Taek ;

Kim, Young Seol ;

Choi, Dong Seop ;

Youn, Byung-Soo ;

Baik, Sei Hyun .

DIABETES, 2012, 61 (11) :2932-2936

[18] MicroRNA-204 regulates vascular smooth muscle cell calcification in vitro and in vivo [J].

Cui, Rong-Rong ;

Li, Shi-Jun ;

Liu, Ling-Juan ;

Yi, Lu ;

Liang, Qiu-Hua ;

Zhu, Xiao ;

Liu, Guan-Ying ;

Liu, Yuan ;

Wu, Shan-Shan ;

Liao, Xiao-Bo ;

Yuan, Ling-Qing ;

Mao, Ding-An ;

Liao, Er-Yuan .

CARDIOVASCULAR RESEARCH, 2012, 96 (02) :320-329

[19] Variations in common diseases, hospital admissions, and deaths in middle-aged adults in 21 countries from five continents (PURE): a prospective cohort study [J].

Dagenais, Gilles R. ;

Leong, Darryl P. ;

Rangarajan, Sumathy ;

Lanas, Fernando ;

Lopez-Jaramillo, Patricio ;

Gupta, Rajeev ;

Diaz, Rafael ;

Avezum, Alvaro ;

Oliveira, Gustavo B. F. ;

Wielgosz, Andreas ;

Parambath, Shameena R. ;

Mony, Prem ;

Alhabib, Khalid F. ;

Temizhan, Ahmet ;

Ismail, Noorhassim ;

Chifamba, Jephat ;

Yeates, Karen ;

Khatib, Rasha ;

Rahman, Omar ;

Zatonska, Katarzyna ;

Kazmi, Khawar ;

Wei, Li ;

Zhu, Jun ;

Rosengren, Annika ;

Vijayakumar, K. ;

Kaur, Manmeet ;

Mohan, Viswanathan ;

Yusufali, AfzalHussein ;

Kelishadi, Roya ;

Teo, Koon K. ;

Joseph, Philip ;

Yusuf, Salim .

LANCET, 2020, 395 (10226) :785-794

[20] Serum C1q/TNF-related protein-3 (CTRP3) levels are decreased in obesity and hypertension and are negatively correlated with parameters of insulin resistance [J].

Deng, Wuquan ;

Li, Changyan ;

Zhang, Yuping ;

Zhao, Jie ;

Yang, Mengliu ;

Tian, Mingyuan ;

Li, Ling ;

Zheng, Yanling ;

Chen, Bing ;

Yang, Gangyi .

DIABETOLOGY & METABOLIC SYNDROME, 2015, 7

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