New Insights Into Implications of CTRP3 in Obesity, Metabolic Dysfunction, and Cardiovascular Diseases: Potential of Therapeutic Interventions

被引：29
作者：
Guo, Bei [1 ,2 ]
Zhuang, Tongtian [3 ]
Xu, Feng [1 ,2 ]
Lin, Xiao [4 ]
Li, Fuxingzi [1 ,2 ]
Shan, Su-Kang [1 ,2 ]
Wu, Feng [5 ]
Zhong, Jia-Yu [1 ,2 ]
Wang, Yi [1 ,2 ]
Zheng, Ming-Hui [1 ,2 ]
Xu, Qiu-Shuang [1 ,2 ]
Ehsan, Ullah Muhammad Hasnain [1 ,2 ]
Yuan, Ling-Qing [1 ,2 ]
机构：
[1] Cent South Univ, Natl Clin Res Ctr Metab Dis, Hunan Prov Key Lab Metab Bone Dis, Xiangya Hosp 2, Changsha, Peoples R China
[2] Cent South Univ, Xiangya Hosp 2, Dept Endocrinol & Metab, Changsha, Peoples R China
[3] Fourth Mil Med Univ, Xijing Hosp, Dept Dermatol, Xian, Peoples R China
[4] Cent South Univ, Dept Radiol, Xiangya Hosp 2, Changsha, Peoples R China
[5] Cent South Univ, Dept Pathol, Xiangya Hosp 2, Changsha, Peoples R China
来源：
FRONTIERS IN PHYSIOLOGY | 2020年 / 11卷
基金：
中国国家自然科学基金;
关键词：
adipocytokines; CTRP3; insulin resistance; therapeutic targets; type 2 diabetes mellitus; obesity; metabolic syndrome; cardiovascular disorders; FACTOR-RELATED PROTEIN-3; REPEAT-CONTAINING SEQUENCE; MUSCLE-CELL CALCIFICATION; C1Q/TNF-RELATED PROTEIN-3; ADIPOSE-TISSUE; COLLAGENOUS REPEAT; OXIDATIVE STRESS; ADIPONECTIN MULTIMERIZATION; CHROMOSOMAL LOCALIZATION; PROMOTES PROLIFERATION;
D O I：
10.3389/fphys.2020.570270
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Adipose tissue, as the largest endocrine organ, secretes many biologically active molecules circulating in the bloodstream, collectively termed adipocytokines, which not only regulate the metabolism but also play a role in pathophysiological processes. C1q tumor necrosis factor (TNF)-related protein 3 (CTRP3) is a member of C1q tumor necrosis factor-related proteins (CTRPs), which is a paralog of adiponectin. CTRP3 has a wide range of effects on glucose/lipid metabolism, inflammation, and contributes to cardiovascular protection. In this review, we comprehensively discussed the latest research on CTRP3 in obesity, diabetes, metabolic syndrome, and cardiovascular diseases.
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页数：11
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