An Organocatalytic Azide-Aldehyde [3+2] Cycloaddition: High-Yielding Regioselective Synthesis of 1,4-Disubstituted 1,2,3-Triazoles

被引：190

作者：

Ramachary, Dhevalapally B. ^{[1
]}

Shashank, Adluri B. ^{[1
]}

Karthik, S. ^{[1
]}

机构：

[1] Univ Hyderabad, Catalysis Lab, Sch Chem, Hyderabad 500046, Andhra Pradesh, India

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2014年 / 53卷 / 39期

关键词：

1,2,3-triazoles; aldehydes; azides; click chemistry; organocatalysis; RUTHENIUM-CATALYZED CYCLOADDITION; FREE CLICK CHEMISTRY; ALKYNE CYCLOADDITION; DIRECT ACCESS; TRIAZOLINES; EFFICIENT; INHIBITOR; KETONES; STRAIN; AMINE;

D O I：

10.1002/anie.201406721

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An organocatalytic azide-aldehyde [3+2] cycloaddition (organo-click) reaction of a variety of enolizable aldehydes is reported. The organo-click reaction is characterized by a high rate and regioselectivity, mild reaction conditions, easily available substrates with simple operation, and excellent yields with a broad spectrum of substrates. It constitutes an alternative to the previously known CuAAC, RuAAC, and IrAAC click reactions.

引用

页码：10420 / 10424

页数：5

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