Bead-isolated human CN4+CD25+ T regulatory cells are anergic and significantly suppress proliferation of CD4+CD25- T responder cells

被引：3
作者：
Elkord, Eyad [1 ]
Hopcraft, Lucy [1 ]
Burt, Debbie [1 ]
Stern, Peter L. [1 ]
机构：
[1] Univ Manchester, Paterson Inst Canc Res, CRUK Immunol Grp, Manchester M20 4BX, Lancs, England
来源：
CLINICAL IMMUNOLOGY | 2006年 / 120卷 / 02期
关键词：
D O I：
10.1016/j.clim.2006.02.007
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
引用
收藏
页码：232 / 233
页数：2
相关论文
共 6 条
[1]   Functional analysis of highly defined, FACS-isolated populations of human regulatory CD4+CD25+ T cells [J].
Baecher-Allan, C ;
Wolf, E ;
Hafler, DA .
CLINICAL IMMUNOLOGY, 2005, 115 (01) :10-18
[2]   Ex vivo isolation and characterization of CD4+CD25+ T cells with regulatory properties from human blood [J].
Dieckmann, D ;
Plottner, H ;
Berchtold, S ;
Berger, T ;
Schuler, G .
JOURNAL OF EXPERIMENTAL MEDICINE, 2001, 193 (11) :1303-1310
[3]   Identification and functional characterization of human CD4+CD25+ T cells with regulatory properties isolated from peripheral blood [J].
Jonuleit, H ;
Schmitt, E ;
Stassen, M ;
Tuettenberg, A ;
Knop, J ;
Enk, AH .
JOURNAL OF EXPERIMENTAL MEDICINE, 2001, 193 (11) :1285-1294
[4]   Human CD25+CD4+ T regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function [J].
Levings, MK ;
Sangregorio, R ;
Roncarolo, MG .
JOURNAL OF EXPERIMENTAL MEDICINE, 2001, 193 (11) :1295-1301
[5]   Naturally arising CD4+ regulatory T cells for immunologic self-tolerance and negative control of immune responses [J].
Sakaguchi, S .
ANNUAL REVIEW OF IMMUNOLOGY, 2004, 22 :531-562
[6]   Functional assay for human CD4+CD25+ Treg cells reveals an age-dependent loss of suppressive activity [J].
Tsaknaridis, L ;
Spencer, L ;
Culbertson, N ;
Hicks, K ;
LaTocha, D ;
Chou, YK ;
Whitham, RH ;
Bakke, A ;
Jones, RE ;
Offner, H ;
Bourdette, DN ;
Vandenbark, AA .
JOURNAL OF NEUROSCIENCE RESEARCH, 2003, 74 (02) :296-308
1