Facile preparation of α-acyloxyacetaldehyde, a versatile intermediate in the synthesis of antiviral nucleosides

被引：13

作者：

Du, JF ^{[1
]}

Watanabe, KA ^{[1
]}

机构：

[1] Pharmasset Inc, Tucker, GA 30084 USA

来源：

SYNTHETIC COMMUNICATIONS | 2004年 / 34卷 / 11期

关键词：

nucleosides; synthesis; HIV-1; HBV;

D O I：

10.1081/SCC-120037904

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This report describes a novel and simple method for the preparation of a versatile intermediate, alpha-acyloxyacetaldehyde and its acetals, and its application to the synthesis of 4-acetoxy-2-acyloxymethyl-1,3-oxathiolane, an important intermediate in the synthesis of biologically active nucleosides.

引用

页码：1925 / 1930

页数：6

共 28 条

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[2]

BELLEAU B, 1989, 5 INT C AIDS MONTR C

[3]

Belleau B, 1991, New 2-hydroxymethyl-5-substituted-13-oxathiolane derivativesuUseful as anti-retroviral agents for treating HIV infections, Patent No. [US5047407, 5047407]

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