Epidemiological changes in cutaneous lymphomas: an analysis of 8593 patients from the French Cutaneous Lymphoma Registry

被引：49

作者：

Dobos, G. ^{[1
,3
,4
]}

de Masson, A. ^{[1
,3
,4
]}

Ram-Wolff, C. ^{[1
,3
,4
]}

Beylot-Barry, M. ^{[5
]}

Pham-Ledard, A. ^{[5
]}

Ortonne, N. ^{[7
]}

Ingen-Housz-Oro, S. ^{[8
]}

Battistella, M. ^{[2
,3
,4
]}

D'Incan, M. ^{[9
]}

Rouanet, J. ^{[10
,11
]}

Franck, F. ^{[10
,11
]}

Vignon-Pennamen, M. D. ^{[2
]}

Franck, N. ^{[12
]}

Carlotti, A. ^{[13
]}

Boulinguez, S. ^{[14
]}

Lamant, L. ^{[15
]}

Petrella, T. ^{[16
]}

Dalac, S. ^{[17
]}

Joly, P. ^{[18
]}

Courville, P. ^{[19
]}

Rivet, J. ^{[5
,7
]}

Dereure, O. ^{[20
]}

Amatore, F. ^{[21
]}

Taix, S. ^{[22
]}

Grange, F. ^{[23
]}

Durlach, A. ^{[24
]}

Quereux, G. ^{[25
]}

Josselin, N. ^{[26
]}

Moulonguet, I ^{[1
]}

Mortier, L. ^{[27
]}

Dubois, R. ^{[28
]}

Maubec, E. ^{[29
]}

Laroche, L. ^{[29
]}

Michel, L. ^{[3
,4
]}

Templier, I ^{[30
]}

Barete, S. ^{[31
]}

Nardin, C. ^{[32
,33
,34
]}

Augereau, O. ^{[6
]}

Vergier, B. ^{[6
]}

Bagot, M. ^{[1
,3
,4
]}

机构：

[1] St Louis Hosp, AP HP, Dermatol Dept, Paris, France

[2] St Louis Hosp, AP HP, Pathol Dept, Paris, France

[3] INSERM, U976 Human Immunol Pathophysiol & Immune Therapie, Paris, France

[4] Univ Paris, Paris, France

[5] Univ Bordeaux, Dermatol Dept, St Andre Hosp, Bordeaux Univ Hosp,INSERM,U1053,UMR BaRITOn,Eq On, Bordeaux, France

[6] Univ Bordeaux, Pathol Dept, St Andre Hosp, Bordeaux Univ Hosp,INSERM,U1053,UMR BaRITOn,Eq On, Bordeaux, France

[7] Univ Paris Est, Henri Mondor Hosp, AP HP, Pathol Dept,INSERM,U955, Paris, France

[8] Univ Paris Est, Henri Mondor Hosp, AP HP, Dermatol Dept,INSERM,U955, Paris, France

[9] Univ Clermont Ferrand, Estaing Univ Hosp, Dermatol & Cutaneous Oncol, Clermont Ferrand, France

[10] NHE Clermont, Pathol Dept, Clermont Ferrand, France

[11] SIPATH UNILABS, Clermont Ferrand, France

[12] Cochin Hosp, AP HP, Dermatol Dept, Paris, France

[13] Cochin Hosp, AP HP, Pathol Dept, Paris, France

[14] Cahors Hosp, Dermatol Dept, Toulouse, France

[15] Inst Univ Canc Toulouse, Pathol & Cytopathol Dept, Toulouse, France

[16] Dijon Bourgogne Univ Hosp, Pathol Dept, Dijon, France

[17] Dijon Bourgogne Univ Hosp, Dermatol Dept, Dijon, France

[18] Rouen Univ Hosp, Rouen Inst Res & Innovat Biomed, Dermatol Dept, INSERM,U1234, Rouen, France

[19] Rouen Univ Hosp, Rouen Inst Res & Innovat Biomed, Pathol Dept, INSERM,U1234, Rouen, France

[20] Montpellier Univ Hosp, Dermatol Dept, Montpellier, France

[21] Aix Marseille Univ, Timone Hosp, AP HM, Dept Dermatol & Oncodermatol, Marseille, France

[22] Aix Marseille Univ, Timone Hosp, AP HM, Dept Pathol, Marseille, France

[23] Robert Debre Univ Hosp, Dermatol Dept, Reims, France

[24] Reims Univ Hosp, Pathol Dept, Reims, France

[25] Nantes Univ Hosp, Dermatol Dept, Nantes, France

[26] Nantes Univ Hosp, Pathol Dept, Nantes, France

[27] Univ Lille, Claude Huriez Univ Hosp, Dermatol Dept, INSERM,U1189, Lille, France

[28] Claude Huriez Univ Hosp, Pathol Dept, Lille, France

[29] Avicenne Hosp, AP HP, Dermatol Dept, Paris, France

[30] Grenoble Univ Hosp, Dermatol Dept, Grenoble, France

[31] Pite Salpetriere Hosp, AP HP, Dermatol Dept, Paris, France

[32] Jean Minjoz Hosp, Dermatol Dept, Besancon, France

[33] Univ Franche Comte, INSERM, U1098, EFS Bourgogne Franche Comte, Besancon, France

[34] Franche Comte Univ, Besancon, France

来源：

BRITISH JOURNAL OF DERMATOLOGY | 2021年 / 184卷 / 06期

关键词：

FOLLICULOTROPIC MYCOSIS-FUNGOIDES; WHO-EORTC CLASSIFICATION; T-CELL LYMPHOMA; SEZARY-SYNDROME; SINGLE-CENTER; TASK-FORCE; PROPOSAL; SURVIVAL; MARKERS; ISCL;

D O I：

10.1111/bjd.19644

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Background Primary cutaneous lymphomas (PCLs) are a heterogeneous group of Tcell (CTCL) and B-cell (CBCL) malignancies. Little is known about their epidemiology at initial presentation in Europe and about potential changes over time. Objectives The aim of this retrospective study was to analyse the frequency of PCLs in the French Cutaneous Lymphoma Registry (GFELC) and to describe the demography of patients. Methods Patients with a centrally validated diagnosis of primary PCL, diagnosed between 2005 and 2019, were included. Results The calculated incidence was unprecedently high at 1.06 per 100 000 person-years. The number of included patients increased yearly. Most PCL subtypes were more frequent in male patients, diagnosed at a median age of 60 years. The relative frequency of rare CTCL remained stable, the proportion of classical mycosis fungoides (MF) decreased, and the frequency of its variants (e.g. folliculotropic MF) increased. Similar patterns were observed for CBCL; for example, the proportion of marginal-zone CBCL increased over time. Conclusions Changes in PCL frequencies may be explained by the emergence of new diagnostic criteria and better description of the entities in the most recent PCL classification. Moreover, we propose that an algorithm should be developed to confirm the diagnosis of PCL by central validation of the cases. What is already known about this topic? Primary cutaneous lymphomas (PCLs) are a heterogeneous group of diseases. Little is known about changes over time in their epidemiology and about patients' characteristics and disease stages at the initial presentation.

引用

页码：1059 / 1067

页数：9

共 27 条

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