Sex differences in systemic morphine analgesic tolerance following intrathecal morphine injections

被引：23
作者：
Hopkins, E
Rossi, G
Kest, B
机构：
[1] CUNY Coll Staten Isl, Dept Psychol, Staten Isl, NY 10314 USA
[2] CUNY Coll Staten Isl, Ctr Dev Neurosci, Staten Isl, NY 10314 USA
[3] CUNY Queens Coll, Neuropsychol Doctoral Subprogram, Flushing, NY 11367 USA
[4] Long Isl Univ, CW Post Coll, Dept Psychol, Brookville, NY 11548 USA
来源：
BRAIN RESEARCH | 2004年 / 1014卷 / 1-2期
关键词：
morphine; tolerance; sex difference; spinal cord;
D O I：
10.1016/j.brainres.2004.03.056
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Morphine analgesic potency following systemic administration was assessed in male and female mice undergoing prior and repeated intrathecal morphine injections. Although morphine ED50 values were significantly increased in both sexes relative to their respective saline-injected controls, the magnitude of tolerance was greater in females. Intrathecal injection alone had no effect on morphine analgesia. The data suggest that spinal mechanisms contribute to sex differences in analgesic tolerance following systemic morphine administration. (C) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码：244 / 246
页数：3
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