Uptake and biological effects of synthetic glucocorticoids in common carp (Cyprinus carpio)

被引：14

作者：

Nakayama, Kei ^{[1
]}

Inoue, Yoshiyuki ^{[2
]}

Ikeda, Naomi ^{[2
]}

Hashizume, Naoki ^{[2
]}

Murakami, Hidekazu ^{[2
]}

Ishibashi, Takeshi ^{[2
]}

Ikeda, Hirofumi ^{[1
]}

Isobe, Tomohiko ^{[1
]}

Kitamura, Shin-Ichi ^{[1
]}

Suzuki, Go ^{[3
]}

机构：

[1] Ehime Univ, Ctr Marine Environm Studies, Matsuyama, Ehime 7908577, Japan

[2] CERI Kurume, Chem Evaluat & Res Inst, Kurume, Fukuoka 8390801, Japan

[3] Natl Inst Environm Studies, Tsukuba, Ibaraki 3058506, Japan

来源：

MARINE POLLUTION BULLETIN | 2014年 / 85卷 / 02期

关键词：

Glucocorticoid; Common carp; Bioconcentration factor; Blood cell composition; Glucose; Free amino acid; SOLEA-SENEGALENSIS KAUP; AMINO-ACIDS; TAURINE; DEXAMETHASONE; APOPTOSIS; CORTISOL; STRESS; GROWTH;

D O I：

10.1016/j.marpolbul.2014.01.042

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Uptake and biological effects of synthetic glucocorticoids (GCs) were analyzed using common carp (Cyprinus carpio). Fish were exposed to clobetasol propionate (CP) or clobetasone butyrate (CB) individually or in mixture at 1 mu g L-1 for 21 days. Bioconcentration factor (BCF) of CB was calculated as 100, and BCF of CP was less than 16. No effects were found in fish erythrocyte and leukocyte numbers and serum glucose levels after exposure to the selected GCs. On the other hand, serum concentrations of free amino acids significantly increased in GC-exposed groups. Thus, exposures to synthetic GCs at relatively low concentrations seemed to cause enhancement of protein degradation and subsequent increase of serum free amino acids without a corresponding increase in serum glucose levels, an effect which might be related to partial induction of gluconeogenesis by GC. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：370 / 375

页数：6

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