Mass Spectrometry Methods for Studying Structure and Dynamics of Biological Macromolecules

被引:106
作者
Konermann, Lars [1 ]
Vahidi, Siavash [1 ]
Sowole, Modupeola A. [1 ]
机构
[1] Univ Western Ontario, Dept Chem, London, ON N6A 5B7, Canada
基金
加拿大自然科学与工程研究理事会; 加拿大创新基金会;
关键词
FAST PHOTOCHEMICAL OXIDATION; AMIDE HYDROGEN/DEUTERIUM EXCHANGE; ELECTRON-CAPTURE DISSOCIATION; PROTEIN-LIGAND INTERACTIONS; ION MOBILITY SPECTROMETRY; CHARGE-STATE DISTRIBUTIONS; CHEMICAL CROSS-LINKING; LASER-DESORPTION IONIZATION; HYDROGEN-EXCHANGE; GAS-PHASE;
D O I
10.1021/ac4039306
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
[No abstract available]
引用
收藏
页码:213 / 232
页数:20
相关论文
共 320 条
[1]   Gas-phase processes and measurements of macromolecular properties in solution: On the possibility of false positive and false negative signals of protein unfolding [J].
Abzalimov, Rinat R. ;
Frimpong, Agya K. ;
Kaltashov, Igor A. .
INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, 2006, 253 (03) :207-216
[2]   A New Approach to Measuring Protein Backbone Protection with High Spatial Resolution Using H/D Exchange and Electron Capture Dissociation [J].
Abzalimov, Rinat R. ;
Bobst, Cedric E. ;
Kaltashov, Igor A. .
ANALYTICAL CHEMISTRY, 2013, 85 (19) :9173-9180
[3]   Structural characterization of protein-polymer conjugates. I. Assessing heterogeneity of a small PEGylated protein and mapping conjugation sites using ion exchange chromatography and top-down tandem mass spectrometry [J].
Abzalimov, Rinat R. ;
Frimpong, Agya ;
Kaltashov, Igor A. .
INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, 2012, 312 :135-143
[4]   Accessing the reproducibility and specificity of pepsin and other aspartic proteases [J].
Ahn, Joomi ;
Cao, Min-Jie ;
Yu, Ying Qing ;
Engen, John R. .
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 2013, 1834 (06) :1222-1229
[5]   Pepsin Immobilized on High-Strength Hybrid Particles for Continuous Flow Online Digestion at 10 000 psi [J].
Ahn, Joomi ;
Jung, Moon Chul ;
Wyndham, Kevin ;
Yu, Ying Qing ;
Engen, John R. .
ANALYTICAL CHEMISTRY, 2012, 84 (16) :7256-7262
[6]   ClpP: A structurally dynamic protease regulated by AAA+ proteins [J].
Alexopoulos, John A. ;
Guarne, Alba ;
Ortega, Joaquin .
JOURNAL OF STRUCTURAL BIOLOGY, 2012, 179 (02) :202-210
[7]   Effects of Polarity on the Structures and Charge States of Native-Like Proteins and Protein Complexes in the Gas Phase [J].
Allen, Samuel J. ;
Schwartz, Alicia M. ;
Bush, Matthew F. .
ANALYTICAL CHEMISTRY, 2013, 85 (24) :12055-12061
[8]   Analytical and bioanalytical technologies for characterizing antibody-drug conjugates [J].
Alley, Stephen C. ;
Anderson, Kevin E. .
CURRENT OPINION IN CHEMICAL BIOLOGY, 2013, 17 (03) :406-411
[9]   Computing H/D-Exchange rates of single residues from data of proteolytic fragments [J].
Althaus E. ;
Canzar S. ;
Ehrler C. ;
Emmett M.R. ;
Karrenbauer A. ;
Marshall A.G. ;
Meyer-Bäse A. ;
Tipton J.D. ;
Zhang H.-M. .
BMC Bioinformatics, 2010, 11 (1)
[10]   Spatially Resolved Protein Hydrogen Exchange Measured by Subzero-Cooled Chip-Based Nanoelectrospray Ionization Tandem Mass Spectrometry [J].
Amon, Sabine ;
Trelle, Morten B. ;
Jensen, Ole N. ;
Jorgensen, Thomas J. D. .
ANALYTICAL CHEMISTRY, 2012, 84 (10) :4467-4473