Antioxidants and lipid peroxidation status in the blood of patients with psoriasis

被引：73
作者：
Kökçam, I
Naziroglu, M [1 ]
机构：
[1] Firat Univ, Fac Vet, Dept Physiol, TR-23119 Elazig, Turkey
[2] Firat Univ, Fac Med, Dept Dermatol, TR-23119 Elazig, Turkey
来源：
CLINICA CHIMICA ACTA | 1999年 / 289卷 / 1-2期
关键词：
psoriasis; lipid peroxidation; antioxidants; vitamin E; beta carotene;
D O I：
10.1016/S0009-8981(99)00150-3
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
The aim of this research was to determine levels in blood of vitamin E, beta carotene, lipid peroxidation as malondialdehyde (MDA), reduced glutathione (GSH) and glutathione peroxidase (GSH-Px) activity in patients with psoriasis. Studies were carried out on 34 patients with moderate and severe psoriases and healthy age-matched controls. Red blood cell (RBC) and plasma samples from healthy and patient subjects were taken. Levels of GSH and the activity of GSH-Px in both plasma and RBC samples were significantly (P < 0.001) lower in patients with psoriasis than in controls, whereas beta carotene levels in plasma and MDA levels in RBC samples were significantly (P < 0.01, P < 0.001) higher in patients with psoriasis than in controls. However, vitamin E and MDA levels in plasma did not differ statistically. Although being far from conclusive, these results provide some evidence for a potential role of increased lipid peroxidation and decreased antioxidants in psoriasis. (C) 1999 Published by Elsevier Science BN. All rights reserved.
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页码：23 / 31
页数：9
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