Management of squamous cell vulvar cancer: A review

被引：18
作者：
Deppe, Gunter [1 ,2 ]
Mert, Ismail [1 ]
Winer, Ira S. [1 ,2 ]
机构：
[1] Wayne State Univ, Dept Obstet & Gynecol, Detroit, MI USA
[2] Wayne State Univ, Div Gynecol Oncol, Detroit, MI USA
来源：
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH | 2014年 / 40卷 / 05期
关键词：
review; squamous cell cancer; vulvar cancer; GYNECOLOGIC-ONCOLOGY-GROUP; LOCALLY ADVANCED-CARCINOMA; SEPARATE GROIN INCISIONS; LYMPH-NODE METASTASES; PHASE-II TRIAL; RADIATION-THERAPY; RADICAL VULVECTOMY; NEOADJUVANT CHEMOTHERAPY; INGUINAL LYMPHADENECTOMY; PROGNOSTIC-FACTORS;
D O I：
10.1111/jog.12352
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Squamous cell vulvar cancer is a rare gynecologic malignancy. Standard treatment for early stage disease consists of wide radical excision of the primary tumor with inguinal-femoral lymphadenectomy or sentinel lymph node mapping/biopsy. Because of the general paucity of patients with advanced vulvar cancer, there is no standard therapy for advanced disease and therefore treatment should be individualized. Intergroup trials are needed to clarify the value of chemoradiation, neoadjuvant chemotherapy and targeted therapy in patients with advanced squamous cell cancer of the vulva to identify modalities with the best therapeutic index and lowest morbidity.
引用
收藏
页码：1217 / 1225
页数：9
相关论文
共 91 条
[1]   Complete remission after neoadjuvant chemotherapy of an advanced vulvar cancer patient: A case report [J].
Achilli, Chiara ;
Palaia, Innocenza ;
Perniola, Giorgia ;
Di Donato, Violante ;
Marchetti, Claudia ;
Panici, Pierluigi Benedetti .
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH, 2012, 38 (07) :1036-1039
[2]   Sexual, Psychological, and Relational Functioning in Women after Surgical Treatment for Vulvar Malignancy: A Literature Review [J].
Aerts, Leen ;
Enzlin, Paul ;
Vergote, Ignace ;
Verhaeghe, Johan ;
Poppe, Willy ;
Amant, Frederic .
JOURNAL OF SEXUAL MEDICINE, 2012, 9 (02) :361-371
[3]   Tailoring the Treatment of Locally Advanced Squamous Cell Carcinoma of the Vulva: Neoadjuvant Chemotherapy Followed by Radical Surgery Results From a Multicenter Study [J].
Aragona, Alejandro M. ;
Cuneo, Nicasio ;
Soderini, Alejandro H. ;
Alcoba, Elsa ;
Greco, Adriana ;
Reyes, Carlos ;
Lekmann, Silvia .
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 2012, 22 (07) :1258-1263
[4]   Single agent cisplatin chemotherapy in surgically resected vulvar cancer patients with multiple inguinal lymph node metastases [J].
Bellati, F ;
Angioli, R ;
Manci, N ;
Zullo, MA ;
Muzii, L ;
Plotti, F ;
Basile, S ;
Panici, PB .
GYNECOLOGIC ONCOLOGY, 2005, 96 (01) :227-231
[5]   Platinum-Based Combination Chemotherapy for the Treatment of Advanced-Stage Squamous Cell Carcinoma of the Vulva [J].
Belotte, Jimmy ;
Awonuga, Awoniyi O. ;
Bolinjkar, Rashmi ;
Alexis, Mitchell ;
Tabassum, Farah ;
Deppe, Gunter .
OBSTETRICS AND GYNECOLOGY, 2012, 120 (02) :458-460
[6]   CISPLATIN (P), BLEOMYCIN (B), AND METHOTREXATE (M) PREOPERATIVE CHEMOTHERAPY IN LOCALLY ADVANCED VULVAR CARCINOMA [J].
BENEDETTIPANICI, P ;
GREGGI, S ;
SCAMBIA, G ;
SALERNO, G ;
MANCUSO, S .
GYNECOLOGIC ONCOLOGY, 1993, 50 (01) :49-53
[7]   Preoperative intensity-modulated radiotherapy and chemotherapy for locally advanced vulvar carcinoma [J].
Beriwal, Sushil ;
Coon, Devin ;
Heron, Dwight E. ;
Kelley, Joseph L. ;
Edwards, Robert P. ;
Sukumvanich, Paniti ;
Zorn, Kristin K. ;
Krivak, Thomas C. .
GYNECOLOGIC ONCOLOGY, 2008, 109 (02) :291-295
[8]   RISK-FACTORS FOR THE DEVELOPMENT OF LYMPH-NODE METASTASIS IN VULVAR SQUAMOUS-CELL CARCINOMA [J].
BINDER, SW ;
HUANG, I ;
FU, YS ;
HACKER, NF ;
BEREK, JS .
GYNECOLOGIC ONCOLOGY, 1990, 37 (01) :9-16
[9]   Is there a role for magnetic resonance imaging in the evaluation of inguinal lymph node metastases in patients with vulva carcinoma? [J].
Bipat, Shandra ;
Fransen, Gerwin A. ;
Spijkerboer, Anje M. ;
van der Velden, Jacobus ;
Bossuyt, Patrick M. M. ;
Zwinderman, Aeilko H. ;
Stoker, Jaap .
GYNECOLOGIC ONCOLOGY, 2006, 103 (03) :1001-1006
[10]   COMBINED THERAPY AS AN ALTERNATIVE TO EXENTERATION FOR LOCALLY ADVANCED VULVO-VAGINAL CANCER .2. RESULTS, COMPLICATIONS, AND DOSIMETRIC AND SURGICAL CONSIDERATIONS [J].
BORONOW, RC ;
HICKMAN, BT ;
REAGAN, MT ;
SMITH, RA ;
STEADHAM, RE .
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS, 1987, 10 (02) :171-181
12345678910