Imaging of ex vivo nonmelanoma skin cancers in the optical and terahertz spectral regions

被引：102

作者：

Joseph, Cecil S. ^{[1
]}

Patel, Rakesh ^{[2
]}

Neel, Victor A. ^{[3
]}

Giles, Robert H. ^{[1
]}

Yaroslavsky, Anna N. ^{[2
,3
]}

机构：

[1] Univ Massachusetts Lowell, Submillimeter Wave Technol Lab, Lowell, MA USA

[2] Univ Massachusetts Lowell, Adv Biophoton Lab, Lowell, MA 01854 USA

[3] Massachusetts Gen Hosp, Dept Dermatol, Boston, MA 02114 USA

来源：

JOURNAL OF BIOPHOTONICS | 2014年 / 7卷 / 05期

关键词：

optical imaging; terahertz imaging; polarization; nonmelanoma skin cancer; BASAL-CELL CARCINOMA; IN-VIVO; SPECTROSCOPY; MELANOMA; MARGINS; TISSUES; RANGE; WATER;

D O I：

10.1002/jbio.201200111

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

We tested the hypothesis that polarization sensitive optical and terahertz imaging may be combined for accurate nonmelanoma skin cancer (NMSC) delineation. Nine NMSC specimens were imaged. 513 m and 440 nm wavelengths were used for terahertz and optical imaging, respectively. Histopathology was processed for evaluation. Terahertz reflectance of NMSC was quantified. Our results demonstrate that cross-polarized terahertz images correctly identified location of the tumours, whereas cross-polarized and polarization difference optical images accurately presented morphological features. Cross-polarized terahertz images exhibited lower reflectivity values in cancer as compared to normal tissue. Combination of optical and terahertz imaging shows promise for intraoperative delineation of NMSC ((c) 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)

引用

页码：295 / 303

页数：9

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