Unraveling hepatitis C virus structure

被引：4
作者：
Fauvelle, Catherine [1 ,2 ]
Felmlee, Daniel J. [1 ,2 ]
Baumert, Thomas F. [1 ,2 ,3 ]
机构：
[1] Univ Strasbourg, Inserm, Unit 1110, F-67000 Strasbourg, France
[2] Univ Strasbourg, Strasbourg, France
[3] Hop Univ Strasbourg, Strasbourg, France
来源：
CELL RESEARCH | 2014年 / 24卷 / 04期
关键词：
BROADLY NEUTRALIZING ANTIBODY; CHALLENGE; VACCINE;
D O I：
10.1038/cr.2014.31
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The high variability and the limited knowledge of the structure of the hepatitis C virus (HCV) envelope glycoproteins (GP) are challenging hurdles for vaccine design. Recently, Kong et al. published a new model of HCV E2 GP structure in Science, revealing a globular structure, starkly contrasting from the extended model of class II fusion proteins from other Flaviviridae viruses. © 2014 IBCB, SIBS, CAS.
引用
收藏
页码：385 / 386
页数：2
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