Metal-Free Synthesis of Aryl Ethers in Water

被引：115

作者：

Lindstedt, Erik ^{[1
]}

Ghosh, Raju ^{[1
]}

Olofsson, Berit ^{[1
]}

机构：

[1] Stockholm Univ, Arrhenius Lab, Dept Organ Chem, SE-10691 Stockholm, Sweden

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 23期

基金：

瑞典研究理事会;

关键词：

ONE-POT SYNTHESIS; DIARYLIODONIUM SALTS; ALKYL-ARYL; IODONIUM SALTS; EFFICIENT; IODINE; HALIDES; PHENOLS; ARENES; ACID;

D O I：

10.1021/ol402960f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first arylation of allylic and benzylic alcohols with diaryliodonium salts is reported. The reaction yields alkyl aryl ethers under mild and metal-free conditions. Phenols are arylated to diaryl ethers in good to excellent yields. The reaction employs diaryliodonium salts and sodium hydroxide in water at low temperature, and excess amounts of the coupling partners are avoided.

引用

页码：6070 / 6073

页数：4

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