Significance of High-Sensitivity Cardiac Troponin T in Hypertrophic Cardiomyopathy

被引：123

作者：

Kubo, Toru ^{[1
]}

Kitaoka, Hiroaki ^{[1
]}

Yamanaka, Shigeo ^{[2
]}

Hirota, Takayoshi ^{[1
]}

Baba, Yuichi ^{[1
]}

Hayashi, Kayo ^{[1
]}

Iiyama, Tatsuo ^{[3
]}

Kumagai, Naoko ^{[3
]}

Tanioka, Katsutoshi ^{[1
]}

Yamasaki, Naohito ^{[1
]}

Matsumura, Yoshihisa ^{[1
]}

Furuno, Takashi ^{[1
]}

Sugiura, Tetsuro ^{[2
]}

Doi, Yoshinori L. ^{[1
]}

机构：

[1] Kochi Med Sch, Dept Med & Geriatr, Kochi, Japan

[2] Kochi Med Sch, Dept Lab Med, Kochi, Japan

[3] Kochi Med Sch, Clin Trial Ctr, Kochi, Japan

来源：

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY | 2013年 / 62卷 / 14期

基金：

日本学术振兴会;

关键词：

biomarker; high-sensitivity cardiac troponin T; hypertrophic cardiomyopathy; prognosis; LEFT-VENTRICULAR HYPERTROPHY; MAGNETIC-RESONANCE; CLINICAL-COURSE; DELAYED ENHANCEMENT; ATRIAL-FIBRILLATION; SUDDEN-DEATH; RISK; DYSFUNCTION; ARRHYTHMIAS; SEVERITY;

D O I：

10.1016/j.jacc.2013.03.055

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objectives This study investigated the significance of the serum high-sensitivity cardiac troponin T (hs-cTnT) marker for prediction of adverse events in hypertrophic cardiomyopathy (HCM). Background Although serum cardiac troponins as sensitive and specific markers of myocardial injury have become well-established diagnostic and prognostic markers in acute coronary syndrome, the usefulness of hs-cTnT for prediction of cardiovascular events in patients with HCM is unclear. Methods We performed clinical evaluation, including measurements of hs-cTnT in 183 consecutive patients with HCM. Results Of 183 HCM patients, 99 (54%) showed abnormal hs-cTnT values (>0.014 ng/ml). During a mean follow-up of 4.1 +/- 2.0 years, 32 (32%) of the 99 patients in the abnormal hs-cTnT group, but only 6 (7%) of 84 patients with normal hs-cTnT values, experienced cardiovascular events: cardiovascular deaths, unplanned heart failure admissions, sustained ventricular tachycardia, embolic events, and progression to New York Heart Association functional class III or IV status (hazard ratio [HR]: 5.05, p < 0.001). Abnormal hs-cTnT value remained an independent predictor of these cardiovascular events after multivariate analysis (HR: 3.23, p = 0.012). Furthermore, in the abnormal hs-cTnT group, overall risk increased with an increase in hs-cTnT value (HR: 1.89/hs-cTnT 1 SD increase in the logarithmic scale, 95% confidence interval: 1.13 to 3.15; p = 0.015 [SD: 0.59]). Conclusions In patients with HCM, an abnormal serum concentration of hs-cTnT is an independent predictor of adverse outcome, and a higher degree of abnormality in hs-cTnT value is associated with a greater risk of cardiovascular events. (C) 2013 by the American College of Cardiology Foundation

引用

页码：1252 / 1259

页数：8

共 28 条

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