Hesperidin regresses cardiac hypertrophy by virtue of PPAR-γ agonistic, anti-inflammatory, antiapoptotic, and antioxidant properties

被引:35
作者
Bhargava, Poorva [1 ]
Verma, Vipin Kumar [1 ]
Malik, Salma [1 ]
Khan, Sana Irfan [1 ]
Bhatia, Jagriti [1 ]
Arya, Dharamvir Singh [1 ]
机构
[1] All India Inst Med Sci, Dept Pharmacol, Cardiovasc Res Lab, New Delhi, India
关键词
cardiac hypertrophy (CH); hesperidin (HES); inflammation; isoproterenol (ISO); oxidative stress; peroxisome proliferator-activated receptor gamma (PPAR-gamma); PROLIFERATOR-ACTIVATED RECEPTOR; OXIDATIVE STRESS; HEART-FAILURE; IN-VITRO; LUNG; RATS; EXPRESSION; PROTECTS; EXTRACT; INJURY;
D O I
10.1002/jbt.22283
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Hesperidin (HES), a flavanone glycoside, predominant in citrus fruits, has an agonistic activity on peroxisome proliferator-activated receptor gamma (PPAR-gamma). PPAR-gamma is an inhibitor of cardiac hypertrophy (CH) signaling pathways. In this study, we investigated the cardioprotective effect of HES in isoproterenol (ISO)-induced CH through PPAR-gamma agonistic activity. For this, male albino Wistar rats were divided into six groups (n = 6), that is, normal, ISO-control, HES treatment group (200 mg kg(-1); p.o.), HES per se (200 mg kg(-1); p.o.), enalapril treatment group (30 mg kg(-1); p.o.), and combination group (HES 200 mg kg(-1); p.o.+enalapril 30 mg kg(-1); p.o.). ISO (3 mg kg(-1); s.c.) was administered to all groups except normal and per se to induce CH. HES or enalapril treatment of 28 days significantly attenuated pathological changes, improved cardiac hemodynamics, suppressed oxidative stress, and apoptosis along with an increased PPAR-gamma expression. The combination of enalapril with HES exhibited an effect similar to that of HES or enalapril alone on all the aforementioned parameters. Therefore, HES may be further evaluated as a promising molecule for the alleviation of CH.
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页数:9
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