A Multilevel View of the Development of Alzheimer's Disease

被引：49

作者：

Avila, Jesus ^{[1
,2
]}

Perry, George ^{[3
]}

机构：

[1] UAM, CSIC, Ctr Biol Mol Severo Ochoa, C Nicolas Cabrera 1, Madrid 28049, Spain

[2] Network Ctr Biomed Res Neurodegenerat Dis CIBERNE, Madrid 28031, Spain

[3] Univ Texas San Antonio, Coll Sci, San Antonio, TX 78249 USA

来源：

NEUROSCIENCE | 2021年 / 457卷

关键词：

clinical diagnosis; tau; amyloid; brain waves; claustrum; biomarkers; MILD COGNITIVE IMPAIRMENT; PAIRED HELICAL FILAMENTS; MODE NETWORK FUNCTION; TAU PATHOLOGY; CORE PROTEIN; BETA-PROTEIN; MOUSE MODEL; BRAIN; SLEEP; DEMENTIA;

D O I：

10.1016/j.neuroscience.2020.11.015

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Every year the Alzheimer's Association publishes a report that provides facts and figures indicating the public health, social and economic impact of Alzheimer's disease (AD). In addition, there are a number of reviews on the disease for general readers. Also, at congresses, AD is analyzed at different but not always related levels, leading to an "elephant as seen by blind men situation" for many of the participants. The review presented herein seeks to provide readers with a holistic view of how AD develops from various perspectives: the whole human organism, brain, circuits, neurons, cellular hallmarks, and molecular level. (C) 2020 The Author(s). Published by Elsevier Ltd on behalf of IBRO.

引用

页码：283 / 293

页数：11

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