A Multilevel View of the Development of Alzheimer's Disease

被引：44
作者：
Avila, Jesus [1 ,2 ]
Perry, George [3 ]
机构：
[1] UAM, CSIC, Ctr Biol Mol Severo Ochoa, C Nicolas Cabrera 1, Madrid 28049, Spain
[2] Network Ctr Biomed Res Neurodegenerat Dis CIBERNE, Madrid 28031, Spain
[3] Univ Texas San Antonio, Coll Sci, San Antonio, TX 78249 USA
来源：
NEUROSCIENCE | 2021年 / 457卷
关键词：
clinical diagnosis; tau; amyloid; brain waves; claustrum; biomarkers; MILD COGNITIVE IMPAIRMENT; PAIRED HELICAL FILAMENTS; MODE NETWORK FUNCTION; TAU PATHOLOGY; CORE PROTEIN; BETA-PROTEIN; MOUSE MODEL; BRAIN; SLEEP; DEMENTIA;
D O I：
10.1016/j.neuroscience.2020.11.015
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Every year the Alzheimer's Association publishes a report that provides facts and figures indicating the public health, social and economic impact of Alzheimer's disease (AD). In addition, there are a number of reviews on the disease for general readers. Also, at congresses, AD is analyzed at different but not always related levels, leading to an "elephant as seen by blind men situation" for many of the participants. The review presented herein seeks to provide readers with a holistic view of how AD develops from various perspectives: the whole human organism, brain, circuits, neurons, cellular hallmarks, and molecular level. (C) 2020 The Author(s). Published by Elsevier Ltd on behalf of IBRO.
引用
收藏
页码：283 / 293
页数：11
相关论文
共 152 条
[1]   Pushing the Limits of EEG: Estimation of Large-Scale Functional Brain Networks and Their Dynamics Validated by Simultaneous fMRI [J].
Abreu, Rodolfo ;
Simoes, Marco ;
Castelo-Branco, Miguel .
FRONTIERS IN NEUROSCIENCE, 2020, 14
[2]   Gamma Entrainment: Impact on Neurocircuits, Glia, and Therapeutic Opportunities [J].
Adaikkan, Chinnakkaruppan ;
Tsai, Li-Huei .
TRENDS IN NEUROSCIENCES, 2020, 43 (01) :24-41
[3]  
Alonso R, 2017, J ALZHEIMERS DIS, V58, P55, DOI [10.3233/JAD-170058, 10.3233/jad-170058]
[4]  
Alzheimer A, 1995, Clin Anat, V8, P429
[5]   SUB-CORTICAL AFFERENTS TO THE HIPPOCAMPAL-FORMATION IN THE MONKEY [J].
AMARAL, DG ;
COWAN, WM .
JOURNAL OF COMPARATIVE NEUROLOGY, 1980, 189 (04) :573-591
[6]   Role of Tau Protein in Remodeling of Circadian Neuronal Circuits and Sleep [J].
Ames, Mercedes ;
Alaniz, Maria E. ;
Karam, Celine S. ;
Cho, Joshua D. ;
Lopez, Gonzalo ;
Javitch, Jonathan A. ;
Santa-Maria, Ismael .
FRONTIERS IN AGING NEUROSCIENCE, 2019, 11
[7]   Adult hippocampal neurogenesis and cognitive flexibility - linking memory and mood [J].
Anacker, Christoph ;
Hen, Rene .
NATURE REVIEWS NEUROSCIENCE, 2017, 18 (06) :335-346
[8]  
[Anonymous], 1995, HIST NEUROSCIENCE
[9]  
Aschenbrenner AJ., 2020, ALZHEIMERS DEMENT AM, P12
[10]   Role of tau protein in both physiological and pathological conditions [J].
Avila, J ;
Lucas, JJ ;
Pérez, M ;
Hernández, F .
PHYSIOLOGICAL REVIEWS, 2004, 84 (02) :361-384
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