Magnetic Multilamellar Liposomes Produced by In Situ Synthesis of Iron Oxide Nanoparticles: "Magnetonions"

被引：18

作者：

Faure, Chrystel ^{[1
]}

Meyre, Marie-Edith ^{[1
]}

Trepout, Sylvain ^{[2
]}

Lambert, Olivier ^{[2
]}

Lebraud, Eric ^{[3
]}

机构：

[1] Univ Bordeaux 1, Ctr Rech Paul Pascal, CNRS, F-33600 Pessac, France

[2] Univ Bordeaux 1, CNRS, UMR 5248, CBMN, F-33405 Talence, France

[3] Univ Bordeaux 1, CNRS, Inst Chim Mat Condensee Bordeaux, F-33608 Pessac, France

来源：

JOURNAL OF PHYSICAL CHEMISTRY B | 2009年 / 113卷 / 25期

关键词：

VESICLES; PARTICLES; MAGNETOLIPOSOMES; HYPERTHERMIA; SURFACE; MODEL; SPHERULITES(TM); MICROSPHERES; DISPERSIONS; FIBROBLASTS;

D O I：

10.1021/jp901105c

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

We report the formation of magnetic onion-type multilamellar vesicles. Iron oxide nanoparticles (np's) were synthesized inside lipidic multilamellar vesicles by coprecipitation of vesicle-encapsulated Fe2+ and Fe3+ ions induced by HO- diffusion through vesicle lamellae. The iron ion encapsulation efficiency of onions was measured by potentiometry and UV-vis absorbance spectroscopy. Its high value (75 +/- 5% for both Fe2+ and Fe3+) ensures an intravesicular synthesis, as confirmed by cryo-transmission electron microscopy (TEM) imaging. The as-grown nanoparticles are characterized by X-ray diffraction analysis and TEM, and magnetic onions are imaged by cryo-TEM. The np size, controlled by temperature and time, ranges from 3 to 6 nm and is shown to be a key parameter for onion stability.

引用

页码：8552 / 8559

页数：8

共 68 条

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