Expression of lncRNA UCA1 in ovarian cancer and its clinical significance

被引：13
作者：
Qiu, Y. R. [1 ]
Zhao, M. Y. [2 ]
Sun, L. [3 ]
Yang, B. C.
Hei, K. W. [1 ]
Du, X. [4 ]
Li, Y. M. [1 ]
机构：
[1] Tianjin Med Univ, Sch Basic Med Sci, Dept Med Microbiol, 22 Qixiangtai Rd, Tianjin 300070, Peoples R China
[2] Yantai City Zhifu Dist Marternal & Child Hlth Hos, Dept Obstet & Gynecol, Yantai, Shandong, Peoples R China
[3] Tianjin Med Univ, Affiliated Hosp 2, Dept Obstet & Gynecol, Tianjin, Peoples R China
[4] Tianjin Med Univ, Gen Hosp, Dept Obstet & Gynecol, Tianjin, Peoples R China
来源：
EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY | 2017年 / 38卷 / 02期
基金：
中国国家自然科学基金;
关键词：
lncRNA; UCA1; Ovarian cancer; MACC1; Metastasis; LONG NONCODING RNA; STATISTICS; CELLS; PCR;
D O I：
10.12892/ejgo3437.2017
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Objectives: To explore the expression and clinical significance of lncRNA-UCA1 in ovarian cancer. Materials and Methods: The expression pf lncRNA-UCA1 in 26 ovarian cancer tissue and 16 normal and benign ovarian tissue were detected using qRT-PCR method, and the correlation of expression level with clinicopathological features were analyzed. Results: Higher lncRNA-UCA1 expression level were detected in ovarian cancer tissue than those in normal ovarian tissue (p<0.05). There were significant correlations between higher expression of lncRNA-UCA1 with tumor staging (p=0.000), histological grades (p=0.000), peritoneal effusion (p=0.001), and lymph node metastasis (p=0.000), but not with age. Conclusion: lncRNA-UCA1 may play a vital role in the metastasis of ovarian cancer and it is expected to be a potential novel biomarker and therapeutic target of ovarian cancer.
引用
收藏
页码：191 / 195
页数：5
相关论文
共 36 条
[1]   The Coded Functions of Noncoding RNAs for Gene Regulation [J].
An, Sojin ;
Song, Ji-Joon .
MOLECULES AND CELLS, 2011, 31 (06) :491-496
[2]  
[Anonymous], RECENT PAT BIOMARK
[3]   Effect of Screening on Ovarian Cancer Mortality The Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Randomized Controlled Trial [J].
Buys, Saundra S. ;
Partridge, Edward ;
Black, Amanda ;
Johnson, Christine C. ;
Lamerato, Lois ;
Isaacs, Claudine ;
Reding, Douglas J. ;
Greenlee, Robert T. ;
Yokochi, Lance A. ;
Kessel, Bruce ;
Crawford, E. David ;
Church, Timothy R. ;
Andriole, Gerald L. ;
Weissfeld, Joel L. ;
Fouad, Mona N. ;
Chia, David ;
O'Brien, Barbara ;
Ragard, Lawrence R. ;
Clapp, Jonathan D. ;
Rathmell, Joshua M. ;
Riley, Thomas L. ;
Hartge, Patricia ;
Pinsky, Paul F. ;
Zhu, Claire S. ;
Izmirlian, Grant ;
Kramer, Barnett S. ;
Miller, Anthony B. ;
Xu, Jian-Lun ;
Prorok, Philip C. ;
Gohagan, John K. ;
Berg, Christine D. .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2011, 305 (22) :2295-2303
[4]   Cancer of the ovary [J].
Cannistra, SA .
NEW ENGLAND JOURNAL OF MEDICINE, 2004, 351 (24) :2519-2529
[5]   Long non-coding RNA UCA1 increases chemoresistance of bladder cancer cells by regulating Wnt signaling [J].
Fan, Yu ;
Shen, Bing ;
Tan, Mingyue ;
Mu, Xinyu ;
Qin, Yan ;
Zhang, Fang ;
Liu, Yong .
FEBS JOURNAL, 2014, 281 (07) :1750-1758
[6]   Increased expression of the long non-coding RNA UCA1 in tongue squamous cell carcinomas: a possible correlation with cancer metastasis [J].
Fang, Zhengyu ;
Wu, Lamei ;
Wang, Luo ;
Yang, Yang ;
Meng, Yusheng ;
Yang, Hongyu .
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY, 2014, 117 (01) :89-95
[7]   Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008 [J].
Ferlay, Jacques ;
Shin, Hai-Rim ;
Bray, Freddie ;
Forman, David ;
Mathers, Colin ;
Parkin, Donald Maxwell .
INTERNATIONAL JOURNAL OF CANCER, 2010, 127 (12) :2893-2917
[8]  
Fung Michael Fung Kee, 2004, J Obstet Gynaecol Can, V26, P717
[9]   The functional role of long non-coding RNA in human carcinomas [J].
Gibb, Ewan A. ;
Brown, Carolyn J. ;
Lam, Wan L. .
MOLECULAR CANCER, 2011, 10
[10]   Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis [J].
Gupta, Rajnish A. ;
Shah, Nilay ;
Wang, Kevin C. ;
Kim, Jeewon ;
Horlings, Hugo M. ;
Wong, David J. ;
Tsai, Miao-Chih ;
Hung, Tiffany ;
Argani, Pedram ;
Rinn, John L. ;
Wang, Yulei ;
Brzoska, Pius ;
Kong, Benjamin ;
Li, Rui ;
West, Robert B. ;
van de Vijver, Marc J. ;
Sukumar, Saraswati ;
Chang, Howard Y. .
NATURE, 2010, 464 (7291) :1071-U148
1234