Modafinil and unconstrained motor activity in schizophrenia - Double-blind crossover placebo-controlled trial

被引：24

作者：

Farrow, Tom F. D. ^{[1
]}

Hunter, Michael D. ^{[1
]}

Haque, Rozana ^{[1
]}

Spence, Sean A. ^{[1
]}

机构：

[1] Univ Sheffield, Longley Ctr, No Gen Hosp, Acad Clin Psychiat,SCANLab, Sheffield S5 7TJ, S Yorkshire, England

来源：

BRITISH JOURNAL OF PSYCHIATRY | 2006年 / 189卷

关键词：

D O I：

10.1192/bjp.bp.105.017335

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Avolition affects quality of life in chronic schizophrenia. We investigated the effect of modafinil upon unconstrained motor activity in 18 male patients. In a randomised crossover design study, wrist-worn actigraphic monitors were used to objectively record motor activity over a 20 h period. Patients' total activity was significantly greater when given the drug. These data suggest that modafinil increases quantifiable motor behaviour in schizophrenia and may have an impact on avolition.

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收藏

页码：461 / 462

页数：2

相关论文

共 13 条

[1] POSITIVE VS NEGATIVE SCHIZOPHRENIA - A CRITICAL-EVALUATION [J].

ANDREASEN, NC .

SCHIZOPHRENIA BULLETIN, 1985, 11 (03) :380-389

[2]

CEPHALON, 1999, PRESCRIBING INFORM

[3] A prospective trial of modafinil as an adjunctive treatment of major depression [J].

DeBattista, C ;

Lembke, A ;

Solvason, HB ;

Ghebremichael, R ;

Poirier, J .

JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, 2004, 24 (01) :87-90

[4] Structural brain correlates of unconstrained motor activity in people with schizophrenia [J].

Farrow, TFD ;

Hunter, MD ;

Wilkinson, ID ;

Green, RDJ ;

Spence, SA .

BRITISH JOURNAL OF PSYCHIATRY, 2005, 187 :481-482

[5] MINI-MENTAL STATE - PRACTICAL METHOD FOR GRADING COGNITIVE STATE OF PATIENTS FOR CLINICIAN [J].

FOLSTEIN, MF ;

FOLSTEIN, SE ;

MCHUGH, PR .

JOURNAL OF PSYCHIATRIC RESEARCH, 1975, 12 (03) :189-198

[6]

HUNTER MD, 2006, IN PRESS AM J PSYCHI

[7] PATTERNS OF CEREBRAL BLOOD-FLOW IN SCHIZOPHRENIA [J].

LIDDLE, PF ;

FRISTON, KJ ;

FRITH, CD ;

HIRSCH, SR ;

JONES, T ;

FRACKOWIAK, RSJ .

BRITISH JOURNAL OF PSYCHIATRY, 1992, 160 :179-186

[8] Potential brain neuronal targets for amphetamine-, methylphenidate-, and modafinil-induced wakefulness, evidenced by c-fos immunocytochemistry in the cat [J].

Lin, JS ;

Hou, YP ;

Jouvet, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (24) :14128-14133

[9] MODAFINIL BINDS TO THE DOPAMINE UPTAKE CARRIER SITE WITH LOW-AFFINITY [J].

MIGNOT, E ;

NISHINO, S ;

GUILLEMINAULT, C ;

DEMENT, WC .

SLEEP, 1994, 17 (05) :436-437

[10] Diagnostic and Statistical Manual of Mental Disorders [J].

Mittal, Vijay A. ;

Walker, Elaine F. .

PSYCHIATRY RESEARCH, 2011, 189 (01) :158-159