Materials and Techniques for Implantable Nutrient Sensing Using Flexible Sensors Integrated with Metal-Organic Frameworks

被引:114
作者
Ling, Wei [1 ]
Liew, Guoguang [2 ]
Li, Ya [3 ]
Hao, Yafeng [4 ]
Pan, Huizhuo [4 ]
Wang, Hanjie [4 ]
Ning, Baoan [3 ]
Xu, Hang [1 ]
Huang, Xian [1 ]
机构
[1] Tianjin Univ, Dept Biomed Engn, 92 Weijin Rd, Tianjin 300072, Peoples R China
[2] Univ Tunku Abdul Rahman, Dept Mechatron & Biomed Engn, Kajang 43000, Selangor, Malaysia
[3] Tianjin Inst Environm & Operat Med, 1 Dali Rd, Tianjin 300050, Peoples R China
[4] Tianjin Univ, Dept Life Sci, 92 Weijin Rd, Tianjin 300072, Peoples R China
基金
中国国家自然科学基金;
关键词
animal studies; implantable flexible sensors; metal-organic frameworks; multichannel sensors; nutrient sensing; CANCER-CELL-PROLIFERATION; WIRELESS OPTOGENETICS; GLUCOSE SENSOR; ASCORBIC-ACID; METABOLISM; PERSPIRATION; STIMULATION; FABRICATION; ELECTRODES; GLYCINE;
D O I
10.1002/adma.201800917
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The combination of novel materials with flexible electronic technology may yield new concepts of flexible electronic devices that effectively detect various biological chemicals to facilitate understanding of biological processes and conduct health monitoring. This paper demonstrates single- or multichannel implantable flexible sensors that are surface modified with conductive metal-organic frameworks (MOFs) such as copper-MOF and cobalt-MOF with large surface area, high porosity, and tunable catalysis capability. The sensors can monitor important nutriments such as ascorbicacid, glycine, L-tryptophan (L-Trp), and glucose with detection resolutions of 14.97, 0.71, 4.14, and 54.60 x 10(-6) M, respectively. In addition, they offer sensing capability even under extreme deformation and complex surrounding environment with continuous monitoring capability for 20 d due to minimized use of biological active chemicals. Experiments using live cells and animals indicate that the MOF-modified sensors are biologically safe to cells, and can detect L-Trp in blood and interstitial fluid. This work represents the first effort in integrating MOFs with flexible sensors to achieve highly specific and sensitive implantable electrochemical detection and may inspire appearance of more flexible electronic devices with enhanced capability in sensing, energy storage, and catalysis using various properties of MOFs.
引用
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页数:9
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